Person: KARĞIN, DİCLE
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KARĞIN
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DİCLE
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Publication Metadata only Probiotic Foods From Past To Present In Anatolian Culture(2016-09-07) İÇEN, HAYRUNİSA; KARĞIN, DİCLE; AKDUMAN, GÜL; İçen H., Karğın D., Akduman G., Güneş F. E.Publication Metadata only The nutritional properties of the kindergartens’ menus in anatolian side of Istanbul(2018-11-26) AKTAÇ, ŞULE; KARĞIN, DİCLE; SARIKAYA, BUSE; AKTAÇ Ş., KARĞIN D., SARIKAYA B., GÜNEŞ F. E.Publication Metadata only In Vivo Effects on Stress Protein, Genotoxicity, and Oxidative Toxicity Parameters in Oreochromis niloticus Tissues Exposed to Thiamethoxam(SPRINGER INTERNATIONAL PUBLISHING AG, 2021) KARĞIN, DİCLE; Temiz, Ozge; Kargin, Dicle; Cogun, Hikmet Y.This study aimed to observe the effect of toxicity of the pesticide thiamethoxam (TMX) at sublethal concentrations in the liver and brain of Oreochromis niloticus. In the experiment, fish were exposed to 50, 100, and, 150 mg/L with thiamethoxam for 48 h and 15 days. The superoxide dismutase (SOD), catalase (CAT), glutathione S-transferaz (GST), glutathione peroxidase (GPx), and ethoxyresorufin-O-deethylase (EROD) activities; and thiobarbituric acid reactive substance (TBARS), heat shock proteins 70 (HSP70), glutathione (GSH), and genotoxicity parameter 8-hydroxy-2 '-deoxyguanosine (8-OHdG) were analyzed by spectrophotometric methods and ELISA techniques. Depending on time and dose in TMX exposure in liver tissue, a significant decrease in GSH level; an increase in SOD, GST, GPx, and EROD enzyme activities; and HSP70, TBARS, and 8-OHdG levels was determined. In brain tissue, SOD, GST, and EROD enzyme activities, an increase in HSP70, TBARS, and 8-OHdG levels, and a decrease in CAT enzyme activity and GSH levels were determined. In this study, TMX in the concentrations used showed that changes in oxidative stress biomarkers, genotoxicity parameter 8-OHdG levels, and HSP70 levels caused toxic effects in the model organism. As a result of the study, the changes and protective effects of the antioxidant system and stress proteins at the cellular level were determined in sublethal doses of toxic effects caused by TMX in the vital organs of the organism. In this toxicological study, TMX exposure resulted in toxicity to O. niloticus liver and brain tissues, in addition, responses of biomarkers to time and concentrations were determined. As a result of this study, the potential toxic effects of the commonly used pesticide TMX will reveal both the ecological risks of the aquatic organism and the basic data of the safety and risk assessments of O. niloticus consumed as food for human health.Publication Metadata only Changes in Serum Physiological and Biochemical Parameters of Male Swiss Albino Mice After Oral Administration of Metal Oxide Nanoparticles (ZnO, CuO, and ZnO plus CuO)(SPRINGERNATURE, 2021) KARĞIN, DİCLE; Kargin, DicleZinc oxide (ZnO) and copper oxide (CuO) nanoparticles (NPs) are widely used in medicine and industrial fields. They have negative effects such as hematoxic, cytotoxic, and genotoxic on animals. This research aimed to investigate the blood physiological and biochemical responses induced by ZnO-NP and CuO-NP individually or in combination in male Swiss albino mice. For purpose, NPs were given to mice with 100 mu l of water by oral gavage for 14 days. Three sublethal NP dose groups (1, 5, 25 mg/kg/day) and one control group (only received 100 mu l of water) were used in the experiments and serum metabolite (glucose, total protein, total cholesterol, triglyceride, cortisol, blood urea nitrogen, immunoglobulin G, and M), ions (Na, K, Cl, Mg, and Ca), and enzyme (ALT, AST, ALP, and LDH) levels were measured. ZnO-, CuO-, and ZnO+CuO-NPs especially higher doses (5 and 25 mg/kg/day) decreased all serum metabolite (except blood urea nitrogen), ions, and ALP while these nanoparticles increased ALT, AST, LDH, and blood urea nitrogen. These increases/decreases in all serum parameters were generally higher in mice treated with the ZnO+CuO-NP mixture compared to the ZnO-NP and CuO-NP groups alone. The study shows that serum biochemistry profiles can be used as indicators to assess nanoparticle toxicity on lipid, protein, and energy metabolisms, immune and enzyme systems, ion regulation, and tissue functions.Publication Metadata only Evaluation of Nutrition Knowledge of Pregnant Women before and after Nutrition Education according to Sociodemographic Characteristics(TAYLOR & FRANCIS INC, 2018) KARĞIN, DİCLE; Aktac, Sule; Sabuncular, Guleren; Kargin, Dicle; Gunes, Fatma EsraThe aim of this cross-sectional study is to evaluate the effect of nutrition education on nutritional knowledge levels of pregnant women. The study was undertaken on a sample of pregnant women (i = 743) attending health centers in Istanbul for prenatal care. Nutrition knowledge scores were significantly higher in posttest (23.0) than pretest (16.0) after receiving nutrition education (p < .001). Significant differences in pretest (p < .05) but not posttest (p > .05) scores were found for factors, such as education level, work status, and the number of pregnancies; significant differences in both test scores were found for age and nutrition information (p < .05). In conclusion, pregnant women need to be given adequate and appropriate nutrition education for maternal and child health according to sociodemographic characteristics.