Person: GÖREN, MEHMET ZAFER
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GÖREN
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MEHMET ZAFER
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Publication Metadata only Kokain(Akademisyen Yayınevi Kitabevi, 2021-09-01) GÖREN, MEHMET ZAFER; Gören M. Z.Publication Metadata only Studies on Some 3-Oxo-5-benzylidene-6-methyl-(4H) -2-substitutedpyridazines with Antinociceptive and Antiinflammatory Activities(2003-03-01) GÖREN, MEHMET ZAFER; Balkan A., Özkanli F., ÜNSAL TAN O., GÖREN M. Z., TERZİOĞLU BEBİTOĞLU B.In this study, some new 3-oxo-5-benzylidene-6-methyl-(4H)-2-substituted pyridazine derivatives have been prepared by the reaction of 5-substituted benzylidene-6-methyl-(4H)-pyridazin-3-one with several substituted benzoyl-methyl bromides. The structures of the compounds have been elucidated by IR, 1H-NMR and elemental analysis. Antinociceptive (only for compound IIIa) and anti-inflammatory activity studies were evaluated by using in vivo tests. The anti-inflammatory activity was studied by means of the \"carrageenan paw edema\", whereas the \"acetic acid writhing\" test was used to assess the antinociceptive activity. Qualitatively, compound IIIa was shown to exert anti-inflammatory effect as potent as phenylbutazone and antinociceptive effect similar to acetylsalicylic acid.Publication Metadata only Temel farmakokinetik ve farmakodinamik prensipler(Güneş Kitabevi, 2022-09-01) GÖREN, MEHMET ZAFER; Gören M. Z.Publication Metadata only Güncel farmakoloji fizyoloji temelinde hasta odaklı yaklaşım(Güneş Kitabevi, 2022-10-01) GÖREN, MEHMET ZAFER; YEGEN, BERRAK; OKUYAN, BETÜL; Şener G. (Editör), Gören M. Z. (Editör), Okuyan B. (Editör), Yegen B. (Editör)Publication Metadata only Gebeliğin ilk trimestırında iohexol maruziyeti, vaka sunumu(2023-07-01) KAŞKAL, MERT; GÖREN, MEHMET ZAFER; Kaşkal M., Gören M. Z.We report a case of a 38-year old pregnant exposed to iohexol who admitted to our teratology information service (TIS). The data was collected by face to face interview and a written consent was taken. She reported that she was given metoprolol for her chest pain and palpitations and she had underwent a cardiac CT investigation with contrast agent iohexol. The patient became aware of her pregnancy in the 6th week after her last menstrual period and admitted to our TIS for the safety of her pregnancy. Metoprolol was used during the 5th and 6th weeks. Radiology consultation was also asked for checking the safety of the dose of radiation she was exposed. During the follow up, she reported that her pregnancy ended as a miscarriage in the 10th week.Publication Metadata only Renal pathologies and mesalazine use in pregnancy(2022-07-01) KAŞKAL, MERT; GÖREN, MEHMET ZAFER; Vizdiklar C., KAŞKAL M., GÖREN M. Z.Publication Metadata only Synthesis and evaluation of the anticonvulsant activities of some 5-(4-substitutedbenzylidene)-6-methyl-4,5-dihydropyridazine-3(2H)-ones(2004-12-01) GÖREN, MEHMET ZAFER; ÜNSAL TAN O., Balkan A., Aypak C., TERZİOĞLU BEBİTOĞLU B., GÖREN M. Z.In this study, starting from 3-benzylidene-4-oxopentanoic add derivatives (1a-e), having 5-benzylidene-6-methyl-4,5-dihydropyridazine-3(2H)-one (2a-e) structure and their ester (3a-e), hydrazide (4a-e) and acetic acid (5a-e) derivatives were synthesized. The physical properties and UV absorptions of the five starting compounds (1a-e) and twenty target compounds (2a-5e) were determined. Their chemical structures were achieved by IR and 1H-NMR spectral data. Additionally, elemental analysis data of the new compounds (1b, 2b, 3b, 4b, 5b, 3c, 4c, 5c, 2e, 3e, 4e and 5e) were done to identify the structures. Anticonvulsant activities of the target compounds (2a-5e) were screened by pentylenetetrazole seizure model. It was observed that compound 2a showed an anticonvulsant effect similar to ethosuximide concerning the seizure grade.Publication Metadata only Klinik toksikoloji tanı ve tedavi(Nobel Tıp Kitapevi, 2020-03-01) GÖREN, MEHMET ZAFER; Gören M. Z.Publication Metadata only Epidemiyolojik çalışma tasarımları(Nobel Tıp Kitapevi, 2020-10-01) GÖREN, MEHMET ZAFER; Gören M. Z.Publication Metadata only Gebelikte mesalazin kullanımı ve renal patolojiler(2022-07-01) KAŞKAL, MERT; GÖREN, MEHMET ZAFER; Vızdıklar C., Kaşkal M., Gören M. Z.