Publication: Studies on Some 3-Oxo-5-benzylidene-6-methyl-(4H) -2-substitutedpyridazines with Antinociceptive and Antiinflammatory Activities
No Thumbnail Available
Date
2003-03-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
In this study, some new 3-oxo-5-benzylidene-6-methyl-(4H)-2-substituted pyridazine derivatives have been prepared by the reaction of 5-substituted benzylidene-6-methyl-(4H)-pyridazin-3-one with several substituted benzoyl-methyl bromides. The structures of the compounds have been elucidated by IR, 1H-NMR and elemental analysis. Antinociceptive (only for compound IIIa) and anti-inflammatory activity studies were evaluated by using in vivo tests. The anti-inflammatory activity was studied by means of the \"carrageenan paw edema\", whereas the \"acetic acid writhing\" test was used to assess the antinociceptive activity. Qualitatively, compound IIIa was shown to exert anti-inflammatory effect as potent as phenylbutazone and antinociceptive effect similar to acetylsalicylic acid.
Description
Keywords
Tıp, Sağlık Bilimleri, Medicine, Health Sciences, Klinik Tıp (MED), Klinik Tıp, TROPİKAL TIP, Clinical Medicine (MED), CLINICAL MEDICINE, TROPICAL MEDICINE, Farmasötik bilim, Yaşam Bilimleri, Pharmaceutical Science, Life Sciences, 3-Oxo-5-benzylidene-6-methyl-(4H)-2-substituted pyridazines, Anti-inflammatory activity, Antinociceptive activity, Synthesis
Citation
Balkan A., Özkanli F., ÜNSAL TAN O., GÖREN M. Z., TERZİOĞLU BEBİTOĞLU B., "Studies on Some 3-Oxo-5-benzylidene-6-methyl-(4H) -2-substitutedpyridazines with Antinociceptive and Antiinflammatory Activities", Fabad Journal of Pharmaceutical Sciences, cilt.28, sa.1, ss.19-25, 2003