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Cardiovascular regulation through hypothalamic GABA(A) receptors in a genetic absence epilepsy model in rat

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dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsAker, RG; Onat, FY
dc.date.accessioned2022-03-12T16:58:41Z
dc.date.available2022-03-12T16:58:41Z
dc.date.issued2002
dc.description.abstractPurpose: gamma-Aminobutyric acid (GABA) plays a vital role in both central cardiovascular homeostasis and pathogenesis of epilepsy. Epilepsy affects autonomic nervous system functions. In this study, we aimed to clarify the role of GABA(A) receptors in hypothalamic cardiovascular regulation in a genetically determined animal model of absence epilepsy. Methods: Nonepileptic Wistar rats and genetic absence epilepsy rats from Strasbourg (GAERS) were instrumented with a guide cannula for drug injection and extradural electrodes for EEG recording. After a recovery period, iliac arterial catheters were inserted for direct measurement of mean arterial pressure and heart rate. Bicuculline, a GABA(A)-receptor antagonist, was injected into the dorsomedial (DMH) or posterior (PH) hypothalamic nuclei of nonepileptic control rats or GAERS. Blood pressure, heart rate, and EEG recordings were performed in conscious unrestrained animals. Results: Bicuculline injections into the hypothalamus produced increases in blood pressure and heart rate of both control rats and GAERS. The DMH group of GAERS showed a twofold increase in the blood pressure and the heart rate compared with those of control rats. Pressor responses to bicuculline, when microinjected into the PH, were similar in the nonepileptic animals and GAERS. Conversely, the amplitude of tachycardic responses to the administration of bicuculline into the PH was significantly higher in GAERS compared with those of control rats. Conclusions: The bicuculline-induced increases in blood pressure and heart rate were more prominent when given in the DMH of GAERS. These results indicate an increased GABA(A) receptor-mediated cardiovascular response through the DMH in conscious rats with absence epilepsy.
dc.identifier.doi10.1046/j.1528-1157.2002.45200.x
dc.identifier.issn0013-9580
dc.identifier.pubmed11903456
dc.identifier.urihttps://hdl.handle.net/11424/227089
dc.identifier.wosWOS:000174406900001
dc.language.isoeng
dc.publisherBLACKWELL PUBLISHING INC
dc.relation.ispartofEPILEPSIA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectblood pressure
dc.subjectheart rate
dc.subjectabsence epilepsy
dc.subjecthypothalamus
dc.subjectrat
dc.subjectAUTONOMIC NERVOUS-SYSTEM
dc.subjectNON-CONVULSIVE EPILEPSY
dc.subjectDORSOMEDIAL HYPOTHALAMUS
dc.subjectEPILEPTOGENIC ACTIVITY
dc.subjectCARDIAC-ARRHYTHMIAS
dc.subjectSUDDEN-DEATH
dc.subjectHEART-RATE
dc.subjectBICUCULLINE
dc.subjectRESPONSES
dc.subjectSEIZURES
dc.titleCardiovascular regulation through hypothalamic GABA(A) receptors in a genetic absence epilepsy model in rat
dc.typearticle
dspace.entity.typePublication
local.avesis.id2cd86267-9051-49e9-a24c-afe42f381f26
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages8
oaire.citation.endPage114
oaire.citation.issue2
oaire.citation.startPage107
oaire.citation.titleEPILEPSIA
oaire.citation.volume43
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

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