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Cerebellar connections to the dorsomedial and posterior nuclei of the hypothalamus in the rat

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dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsCavdar, S; San, T; Aker, R; Sehirli, U; Onat, F
dc.date.accessioned2022-03-12T16:58:22Z
dc.date.available2022-03-12T16:58:22Z
dc.date.issued2001
dc.description.abstractThe stimulation or ablation of cerebellar structures has produced a variety of visceral responses, indicating a cerebellar role in visceral functions. Studies using anterograde and retrograde tracing methods have revealed connections between the hypothalamus and cerebellar structures. The aim of this study is to investigate the cerebellar connections of the dorsomedial (DMH) and posterior hypothalamic nuclei using retrograde axonal transport of horseradish peroxidase (HRP). In the present study, micro-injection of HRP restricted within the borders of the DMH showed that the projections of this nucleus are not uniform throughout its extent. The posterior DMH receives projections from the cerebellum whereas the anterior DMH does not. These projections were from the (greatest to least concentration) lateral (dentate), anterior interposed (emboliform), and medial (fastigial) cerebellar nuclei. In addition, both the anterior and posterior DMH receive projections from various areas of the brainstem which confirms earlier studies and provides detailed descriptions. This study also demonstrates the distribution of labelled neurons to cerebellar and brainstem nuclei following HRP injection into the posterior hypothalamic nucleus. It provides clear evidence for a direct cerebellar nuclei-posterior DMH and cerebellar nuclei-posterior hypothalamic nucleus connections. We suggest that the brainstem reticular nuclei and other connections, such as the solitary, trigeminal and vestibular nuclei, of both DMH and posterior hypothalamus may contribute to the indirect cerebellohypothalamic connections. These observations offer a new perspective on the question of how the cerebellum may influence autonomic activity.
dc.identifier.doi10.1046/j.1469-7580.2001.19810037.x
dc.identifier.eissn1469-7580
dc.identifier.issn0021-8782
dc.identifier.pubmed11215766
dc.identifier.urihttps://hdl.handle.net/11424/227043
dc.identifier.wosWOS:000166993100004
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF ANATOMY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectdorsomedial hypothalamic nucleus
dc.subjectposterior hypothalamic nucleus
dc.subjectcerebellum
dc.subjectFASTIGIAL NUCLEUS
dc.subjectCARDIOVASCULAR-RESPONSES
dc.subjectFIBERS
dc.subjectSTIMULATION
dc.subjectPATHWAY
dc.subjectBRAIN
dc.subjectAFFERENTS
dc.subjectCIRCUITS
dc.titleCerebellar connections to the dorsomedial and posterior nuclei of the hypothalamus in the rat
dc.typearticle
dspace.entity.typePublication
local.avesis.idcbb8b9b0-5f3a-4d0d-b0b2-16a94024fcb3
local.import.packageSS17
local.indexed.atWOS
local.indexed.atPUBMED
local.journal.numberofpages9
oaire.citation.endPage45
oaire.citation.startPage37
oaire.citation.titleJOURNAL OF ANATOMY
oaire.citation.volume198
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

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