Publication:
Melatonin protects against epirubicin-induced cardiotoxicity

Simple item page
dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsGuven, Aysel; Yavuz, Ozlem; Cam, Meryem; Ercan, Feriha; Bukan, Neslihan; Comunoglu, Cem
dc.date.accessioned2022-03-12T17:33:16Z
dc.date.available2022-03-12T17:33:16Z
dc.date.issued2007
dc.description.abstractWe investigated the cytoprotective effect of melatonin in epirubicin-induced cardiotoxicity using four experimental groups of mate Wistar rats: untreated control rats, epirubicin-treated rats, epirubicin+melatonin-treated rats, and melatonin-treated rats. We examined the histopathological. and biochemical, effects of melatonin on the epirubicin-induced changes and measured the Levels of the lipid peroxication end-product (malondialdehyde, MDA), an indicator of nitric oxide (NO) synthesis (nitrite/nitrate production), and reduced glutathione (GSH) in the heart. We also studied the extracellular matrix components (fibronectin, laminin) in the heart. Vacuole formation, mitochondrial. deformation and degeneration, and disordered myofibrillary structures were detected ultrastructurally in the epirubicin-treated group. The degeneration was reduced in the heart tissues of the epirubicin+melatonin group. Epirubicin increased the nitrite/nitrate production, but did not change the MDA and GSH levels significantly. Melatonin treatment Lowered the nitrite/nitrate concentrations, while increasing the GSH levels, which exceeded the Levels in epirubicin+melatonin-treated rats. We conclude that the epirubicin increased the nitrozative stress, not the oxidative stress, in heart tissue, and the cardioprotective effect of melatonin was partially attributed to the suppression of epirubicin-induced nitrozative stress. These results suggest that melatonin partially protects against epirubicin-induced cardiotoxicity. (C) 2006 Elsevier GmbH. All rights reserved.
dc.identifier.doi10.1016/j.acthis.2006.09.007
dc.identifier.eissn1618-0372
dc.identifier.issn0065-1281
dc.identifier.pubmed17109937
dc.identifier.urihttps://hdl.handle.net/11424/228808
dc.identifier.wosWOS:000244594300006
dc.language.isoeng
dc.publisherELSEVIER GMBH
dc.relation.ispartofACTA HISTOCHEMICA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectepirubicin
dc.subjectcardiotoxicity
dc.subjectnitrite/nitrate production
dc.subjecthistopathology
dc.subjectmelatonin
dc.subjectNITRIC-OXIDE
dc.subjectDOXORUBICIN CARDIOMYOPATHY
dc.subjectLIPID-PEROXIDATION
dc.subjectTOXICITY
dc.subjectINJURY
dc.subjectEXPRESSION
dc.subjectEFFICACY
dc.subjectTHERAPY
dc.subjectHORMONE
dc.subjectOXYGEN
dc.titleMelatonin protects against epirubicin-induced cardiotoxicity
dc.typearticle
dspace.entity.typePublication
local.avesis.idb7a95c03-7bc1-412c-8a6a-b5457ff9b968
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages9
oaire.citation.endPage60
oaire.citation.issue1
oaire.citation.startPage52
oaire.citation.titleACTA HISTOCHEMICA
oaire.citation.volume109
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

Files

Collections

Research Outputs