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Synthesis and characterization of levan hydrogels and their use for resveratrol release

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dc.contributor.authorTOKSOY ÖNER, EBRU
dc.contributor.authorsSelvi, Sinem Selvin; Haskoylu, Merve Erginer; Genc, Seval; Toksoy Oner, Ebru
dc.date.accessioned2022-03-12T22:55:04Z
dc.date.available2022-03-12T22:55:04Z
dc.date.issued2021
dc.description.abstractConsidering the need for systematic studies on levan based hydrogels to widen their use in drug delivery systems and biomedical applications, this study is mainly focused on the synthesis and comprehensive characterization as well as drug release properties of hydrogels based on Halomonas levan (HL) and its chemical derivatives. For this, hydrolyzed and phosphonated HL derivatives were chemically synthesized and then cross-linked with 1,4-Butanediol diglycidyl ether (BDDE) and the obtained hydrogels were characterized in terms of their swelling, adhesivity, and rheological properties. Both native and phosphonated HL hydrogels retained their rigid gel like structure with increasing shear stress levels and tack test analysis showed superior adhesive properties of the phosphonated HL hydrogels. Moreover, hydrogels were loaded with resveratrol and entrapment and release studies as well as cell culture studies with human keratinocytes were performed. Biocompatible and adhesive features of the hydrogels confirmed their suitability for tissue engineering and drug delivery applications.
dc.identifier.doi10.1177/08839115211055725
dc.identifier.eissn1530-8030
dc.identifier.issn0883-9115
dc.identifier.urihttps://hdl.handle.net/11424/236637
dc.identifier.wosWOS:000713403600001
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS LTD
dc.relation.ispartofJOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHalomonas levan
dc.subjectfructan
dc.subjecthydrogels
dc.subjectresveratrol
dc.subjectskin tissue engineering
dc.subjectdrug delivery system
dc.subjectHALOMONAS-SMYRNENSIS
dc.subjectMULTILAYER FILMS
dc.subjectSULFATED LEVAN
dc.subjectIN-VITRO
dc.subjectNANOPARTICLES
dc.subjectSTABILITY
dc.subjectDELIVERY
dc.subjectPH
dc.titleSynthesis and characterization of levan hydrogels and their use for resveratrol release
dc.typearticle
dspace.entity.typePublication
local.avesis.id72456140-aec2-4d0f-9d90-a2666f3d7b17
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumber8839115211055720
local.journal.numberofpages17
oaire.citation.endPage480
oaire.citation.issue6
oaire.citation.startPage464
oaire.citation.titleJOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
oaire.citation.volume36
relation.isAuthorOfPublication6118e9e4-a58e-429b-bbec-4f73a3089a2b
relation.isAuthorOfPublication.latestForDiscovery6118e9e4-a58e-429b-bbec-4f73a3089a2b

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