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Differentiation of K562 Cells Under ELF-EMF Applied at Different Time Courses

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dc.contributor.authorGARİP, GÜNSELİ AYŞE
dc.contributor.authorsAyse, Inhan-Garip; Zafer, Akan; Sule, Oncul; Isil, Isal-Turgut; Kalkan, Tunaya
dc.date.accessioned2022-03-12T17:48:22Z
dc.date.available2022-03-12T17:48:22Z
dc.date.issued2010
dc.description.abstractThe time-course of ELF-EMF application to biological systems is thought to be an important parameter determining the physiological outcome. This study investigated the effect of ELF-EMF on the differentiation of K562 cells at different time courses. ELF-EMF (50 Hz, 5 mT, 1 h) was applied at two different time-courses; first at the onset of hemin induction for 1 h, and second, daily 1 h for four days. While single exposure to ELF-EMF resulted in a decrease in differentiation, ELF-EMF applied everyday for 1 h caused an increase in differentiation. The effect of co-stressors, magnesium, and heat-shock was also determined and similar results were obtained. ELF-EMF increased ROS levels in K562 cells not treated with hemin, however did not change ROS levels of hemin treated cells indicating that ROS was not the cause. Overall, these results imply that the time-course of application is an important parameter determining the physiological response of cells to ELF-EMF.
dc.identifier.doi10.3109/15368378.2010.502451
dc.identifier.eissn1536-8386
dc.identifier.issn1536-8378
dc.identifier.pubmed20707646
dc.identifier.urihttps://hdl.handle.net/11424/229943
dc.identifier.wosWOS:000281889300006
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS INC
dc.relation.ispartofELECTROMAGNETIC BIOLOGY AND MEDICINE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectELF-EMF
dc.subjectDifferentiation
dc.subjectExposure time-course
dc.subjectHeat shock
dc.subjectROS
dc.subjectK562
dc.subjectCHEMICALLY-INDUCED DIFFERENTIATION
dc.subjectELECTROMAGNETIC-FIELDS
dc.subjectINTERMITTENT EXPOSURE
dc.subjectACTIVATION
dc.subjectRESISTANCE
dc.subjectKINASE
dc.subjectGROWTH
dc.titleDifferentiation of K562 Cells Under ELF-EMF Applied at Different Time Courses
dc.typearticle
dspace.entity.typePublication
local.avesis.ide48eff0a-7680-4961-872c-8621ad36a14f
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
oaire.citation.endPage130
oaire.citation.issue3
oaire.citation.startPage122
oaire.citation.titleELECTROMAGNETIC BIOLOGY AND MEDICINE
oaire.citation.volume29
relation.isAuthorOfPublication4e6e5b70-56a5-4519-bbe7-fde9a6ec4775
relation.isAuthorOfPublication.latestForDiscovery4e6e5b70-56a5-4519-bbe7-fde9a6ec4775

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