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Diet-supported aerobic exercise reduces blood endothelin-1 and nitric oxide levels in individuals with impaired glucose tolerance

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsKasimay, Ozgur; Ergen, Nilay; Bilsel, Serpil; Kacar, Omer; Deyneli, Oguzhan; Gogas, Dilek; Akalin, Sema; Yegen, Berrak C.; Kurtel, Hizir
dc.date.accessioned2022-03-12T17:48:43Z
dc.date.available2022-03-12T17:48:43Z
dc.date.issued2010
dc.description.abstractBACKGROUND: Impaired glucose tolerance (IGT) forms an intermediate stage in the natural history of diabetes mellitus. Insulin-resistant states might be associated with dysfunction of the vascular endothelium. OBJECTIVES: To determine the effects of chronic exercise and a low-calorie diet on plasma nitric oxide (NO) and endothelin-1 (ET-1) levels in patients with JOT and to elucidate the relationship between the oxidant stress markers and NO/ET-1 levels of blood before and after exercise. METHODS: Patients with IGT (n = 14) participated in a regular exercise program and exercised for 40 minutes each day, 3 days a week for 12 weeks. Physiological, anthropometric, and biochemical measurements were performed before, during the 6th week, and at the end of the program. RESULTS: There was a significant reduction in body mass index, body fat content, systolic and diastolic blood pressures, as well as NO and ET-1 concentrations after 12 weeks of exercise and diet program. Exercise training significantly elevated subjects' maximum oxygen consumption, whereas the resting metabolic rates of the patients did not change. The formation of thiobarbituric acid reactive substances were significantly reduced, whereas sulfhydryl groups were significantly increased on the 6th week (P < .05) and at the end of program (P < .01). CONCLUSION: Our results demonstrate that exercise, along with low-calorie diet, induced reductions in the plasma of both ET-1 and NO. Beneficial effects were observed on anthropometric measurements and plasma oxidant stress markers, indicating weight loss associated with exercise training and calorie restriction may effectively improve endothelial dysfunction in patients with IGT. (C) 2010 National Lipid Association. All rights reserved.
dc.identifier.doi10.1016/j.jacl.2010.08.001
dc.identifier.eissn1876-4789
dc.identifier.issn1933-2874
dc.identifier.pubmed21122687
dc.identifier.urihttps://hdl.handle.net/11424/230001
dc.identifier.wosWOS:000283566400020
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofJOURNAL OF CLINICAL LIPIDOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBlood pressure
dc.subjectEndothelin-1
dc.subjectExercise
dc.subjectImpaired glucose tolerance
dc.subjectNitric oxide
dc.subjectPlasma sulfhydryl (RSH) groups
dc.subjectPlasma TBARS
dc.subjectTYPE-2 DIABETES-MELLITUS
dc.subjectPLASMA ENDOTHELIN-1
dc.subjectINSULIN-RESISTANCE
dc.subjectDYSFUNCTION
dc.subjectMETABOLISM
dc.subjectHUMANS
dc.subjectSYNTHASE
dc.subjectTISSUE
dc.titleDiet-supported aerobic exercise reduces blood endothelin-1 and nitric oxide levels in individuals with impaired glucose tolerance
dc.typearticle
dspace.entity.typePublication
local.avesis.idae705982-df86-4c9b-8e5e-5e98a6092f6b
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage434
oaire.citation.issue5
oaire.citation.startPage427
oaire.citation.titleJOURNAL OF CLINICAL LIPIDOLOGY
oaire.citation.volume4
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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