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Fabrication of electrospun juglans regia (juglone) loaded poly(lactic acid) scaffolds as a potential wound dressing material

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dc.contributor.authorALTAN, ERAY
dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorULAĞ, SONGÜL
dc.contributor.authorsALTAN E., Karacelebi Y., Saatcioglu E., ULAĞ S., ŞAHİN A., AKSU M. B., Croitoru A., Codrea C. I., Ficai D., GÜNDÜZ O., et al.
dc.date.accessioned2023-05-30T06:37:28Z
dc.date.available2023-05-30T06:37:28Z
dc.date.issued2022-05-01
dc.description.abstractJuglone (5-hydroxy-1,4-naphthoquinone) (J) is a naphthoquinone structured allelochemical that is mostly found in the roots, leaves, nut-hulls, bark, and wood of walnut (Juglans regia). In this study, the biocompatibility, mechanical, thermal, chemical, morphological, and antimicrobial properties of the poly(lactic acid) (PLA) (w/v)/J (10, 20, 30 mg) electrospun scaffolds were investigated. Based on the results of the study, it was shown that juglone addition increased the antimicrobial properties of the scaffolds against the Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), compared to the neat PLA film after 24 h of contact time. According to the tensile test results, the addition of J made the scaffolds more flexible but decreased the mechanical strength. The cytotoxicity properties of the J-added scaffolds demonstrated a toxic behavior on the first day of incubation. However, with an increase in the J ratio, the fibroblast cell metabolic activity increased for all incubation periods.
dc.identifier.citationALTAN E., Karacelebi Y., Saatcioglu E., ULAĞ S., ŞAHİN A., AKSU M. B., Croitoru A., Codrea C. I., Ficai D., GÜNDÜZ O., et al., "Fabrication of Electrospun Juglans regia (Juglone) Loaded Poly(lactic acid) Scaffolds as a Potential Wound Dressing Material", POLYMERS, cilt.14, sa.10, 2022
dc.identifier.doi10.3390/polym14101971
dc.identifier.issn2073-4360
dc.identifier.issue10
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/fed1a98e-f44b-4b68-bf14-75de89fe374e/file
dc.identifier.urihttps://hdl.handle.net/11424/289746
dc.identifier.volume14
dc.language.isoeng
dc.relation.ispartofPOLYMERS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKimya
dc.subjectFizikokimya
dc.subjectPolimer Karakterizasyonu
dc.subjectTemel Bilimler
dc.subjectChemistry
dc.subjectPhysical Chemistry
dc.subjectCharacterization of Polymers
dc.subjectNatural Sciences
dc.subjectPOLİMER BİLİMİ
dc.subjectTemel Bilimler (SCI)
dc.subjectPOLYMER SCIENCE
dc.subjectCHEMISTRY
dc.subjectNatural Sciences (SCI)
dc.subjectPolimerler ve Plastikler
dc.subjectKimya (çeşitli)
dc.subjectGenel Kimya
dc.subjectFizik Bilimleri
dc.subjectPolymers and Plastics
dc.subjectChemistry (miscellaneous)
dc.subjectGeneral Chemistry
dc.subjectPhysical Sciences
dc.subjectelectrospinning
dc.subjectpolylactic acid
dc.subjectjuglone
dc.subjectskin tissue engineering
dc.subjectwound dressing
dc.subjectSKIN
dc.subjectEXTRACT
dc.subjectelectrospinning
dc.subjectpolylactic acid
dc.subjectjuglone
dc.subjectskin tissue engineering
dc.subjectwound dressing
dc.titleFabrication of electrospun juglans regia (juglone) loaded poly(lactic acid) scaffolds as a potential wound dressing material
dc.typearticle
dspace.entity.typePublication
local.avesis.idfed1a98e-f44b-4b68-bf14-75de89fe374e
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
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relation.isAuthorOfPublication.latestForDiscovery96f2a643-9c18-41d4-a7dd-5d79be7199c2

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