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Synthesis, characterization and biological evaluation of novel thiourea derivatives

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dc.contributor.authorTOK, FATİH
dc.contributor.authorsTOK F., Cakir C., Cam D., Kirpat M. M., SICAK Y.
dc.date.accessioned2023-07-25T10:20:22Z
dc.date.available2023-07-25T10:20:22Z
dc.date.issued2022-06-01
dc.description.abstractObjective: A new series of 4-[3-(substitutedphenyl)thioureido]-N-(6-chloropyrazin-2-yl)benzenesulfonamide were synthesized from sulfaclozine. Methods: All compounds were characterized by IR, 1 H-NMR spectroscopic methods and elemental analysis. In addition to the antioxidant activity of the synthesis series, enzyme inhibition activities such as anticholinesterase, tyrosinase, α-amylase and α-glycosidase were determined for the first time in this study. Results: According to these biological activity test results, compound 2a in the DPPH, 2c in the ABTS˙+ assay exhibited more antioxidant activity than reference standard. All thiourea derivatives demonstrated good BChE inhibitory activity than galantamine. Among the compounds, 2e and 2f showed the best tyrosinase enzyme inhibition activity, while 2g had the best α-amylase and α-glucosidase enzyme inhibition activity. In addition, we evaluated the druglikeness properties of compounds and their oral bioavailability were also found to be high. Conclusion: Thiourea derivatives exhibited remarkable antioxidant activity and enzyme inhibition activity against tyrosinase, cholinesterase, α-amylase and α-glucosidase
dc.identifier.citationTOK F., Cakir C., Cam D., Kirpat M. M., SICAK Y., "Synthesis, Characterization and Biological Evaluation of Novel Thiourea Derivatives", CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.12, sa.2, ss.533-540, 2022
dc.identifier.doi10.33808/clinexphealthsci.1062872
dc.identifier.endpage540
dc.identifier.issn2459-1459
dc.identifier.issue2
dc.identifier.startpage533
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/948cb066-2c73-4541-b172-4ee442804caf/file
dc.identifier.urihttps://hdl.handle.net/11424/291575
dc.identifier.volume12
dc.language.isoeng
dc.relation.ispartofCLINICAL AND EXPERIMENTAL HEALTH SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectInternal Medicine Sciences
dc.subjectMedical Ecology and Hydroclimatology
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectMEDICINE, RESEARCH & EXPERIMENTAL
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectAraştırma ve Teori
dc.subjectİncelemeler ve Referanslar (tıbbi)
dc.subjectResearch and Theory
dc.subjectReviews and References (medical)
dc.subjectThiourea
dc.subjectantioxidant
dc.subjectanticholinesterase
dc.subjecttyrosinase
dc.subjectalpha-amylase
dc.titleSynthesis, characterization and biological evaluation of novel thiourea derivatives
dc.typearticle
dspace.entity.typePublication
local.avesis.id948cb066-2c73-4541-b172-4ee442804caf
local.indexed.atWOS
local.indexed.atTRDIZIN
relation.isAuthorOfPublication0a1c1aab-25cc-4eb2-9121-496da16c3ff1
relation.isAuthorOfPublication.latestForDiscovery0a1c1aab-25cc-4eb2-9121-496da16c3ff1

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