Publication:
Fabrication and characterisation studies of cyclodextrin-based nanosponges for sulfamethoxazole delivery

Simple item page
dc.contributor.authorTATAR, ESRA
dc.contributor.authorsYasayan, Gokcen; Sert, Betul Satiroglu; Tatar, Esra; Kucukguzel, Ilkay
dc.date.accessioned2022-03-12T22:39:47Z
dc.date.available2022-03-12T22:39:47Z
dc.date.issued2020
dc.description.abstractbeta-Cyclodextrin based nanosponges have been synthesized in three molar ratios, and characterized by phase solubility studies, Fourier-transform infrared spectroscopy, matrix-assisted laser desorption/ionization time of flight mass spectrometry, and scanning electron microscopy. Following characterization studies, a model anti-bacterial agent, sulfamethoxazole, has been loaded within the nanosponges, and in vitro drug release studies were carried out. According to results, nanosponges below similar to 100 nm diameter were obtained with a characteristic sponge-like morphology. Phase solubility studies demonstrated that beta-cyclodextrin nanosponges improve solubility of the drug up to 30-fold. These results suggest that nanosponges could improve the bioavailability of drugs by conducing them to reach desired plasma concentrations for therapeutic effect. [GRAPHICS] .
dc.identifier.doi10.1007/s10847-020-01003-z
dc.identifier.eissn1573-1111
dc.identifier.issn1388-3127
dc.identifier.urihttps://hdl.handle.net/11424/235870
dc.identifier.wosWOS:000537342000002
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofJOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbeta-Cyclodextrin
dc.subjectNanosponge
dc.subjectCross-linking
dc.subject1,1 '-Carbonyldiimidazole
dc.subjectSulfamethoxazole
dc.subjectDrug release
dc.subjectBETA-CYCLODEXTRIN
dc.subjectSEPTIC ARTHRITIS
dc.subjectCOMPLEXATION
dc.subjectMOLECULES
dc.subjectFORMULATION
dc.subjectINFECTIONS
dc.subjectSKIN
dc.titleFabrication and characterisation studies of cyclodextrin-based nanosponges for sulfamethoxazole delivery
dc.typearticle
dspace.entity.typePublication
local.avesis.idf8b9c52d-4680-42bc-a092-d272f641d192
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages12
local.journal.quartileQ3
oaire.citation.endPage186
oaire.citation.issue3-4
oaire.citation.startPage175
oaire.citation.titleJOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
oaire.citation.volume97
relation.isAuthorOfPublicatione2c939bf-1387-4174-802c-e714419b20af
relation.isAuthorOfPublication.latestForDiscoverye2c939bf-1387-4174-802c-e714419b20af

Files

Collections

Research Outputs