Publication:
Skin autofluorescence Is associated With low bone mineral density in type 2 diabetic patients

Simple item page
dc.contributor.authorYAVUZ, DİLEK
dc.contributor.authorsYavuz, Dilek Gogas; Apaydin, Tugce
dc.date.accessioned2022-03-15T11:34:06Z
dc.date.available2022-03-15T11:34:06Z
dc.date.issued2021
dc.description.abstractAlthough the risk of bone fracture is increased in type 2 diabetes (T2DM), bone mineral density (BMD) is increased rather than decreased. Accumulation of advanced glycation end products (AGEs) adversely influences the fracture resistance of bone in T2DM. We hypothesized that SAF is also associated with BMD levels in type 2 diabetic patients and aimed to evaluate the association of SAF with BMD and the presence of osteoporosis. This cross-sectional case-control study included 237 patients with T2DM (F/M: 133/104, 56.2±11.9 yrs) and 100 age- and sex-matched controls (F/M: 70/30, 54.8±8.8 yrs). Skin autofluorescence, a validated non-invasive measure of tissue AGEs, is used to detect the accumulation of AGEs in skin collagen using AGE Reader (DiagnOptics B.V., Groningen, The Netherlands). In addition, BMD was measured with DEXA (Lunar DPX-L). Patients with T2DM had higher SAF values compared to control group (2.21±0.53 AU vs. 1.79±0.33 AU, p < 0.001). Male subjects had higher SAF compared to women (2.34±0.53 AU vs. 2.11±0.50 AU, p < 0.001). Subjects with below -2.5 femoral neck or lumbar T scores had higher SAF measurements compared to subjects with normal T scores (2.46±0.53 AU vs. 2.18±0.52 AU, p = 0.006). Femoral neck BMD was lower in subjects with T2DM (0.946±0.345 g/cm2 vs. 1.005±0.298 g/cm2, p = 0.002). There was a negative correlation between SAF and femoral neck BMD (r=-0.24, p < 0.001), femoral neck T scores (r=-0.24, p < 0.001), L1-4 BMD (r=-0.10, p = 0.005), L1-4 T score (r=-0.16, p=0.001) and a positive correlation between SAF and age (r=0.44, p < 0.001), body mass index (r:0.16, p = 0.002) and HbA1c (r=0.37, p < 0.001). Accumulation of skin AGEs was increased, and BMD levels were decreased in diabetic patients. A negative association between SAF and BMD was detected, indicating a relationship between higher AGE accumulation and low BMD and osteoporosis in diabetic patients. Long-term prospective studies are needed to identify the practical use of SAF measurement in diabetic bone disease.
dc.identifier.doi10.1016/j.jocd.2021.11.010
dc.identifier.issn1094-6950
dc.identifier.pubmedPMID: 34933784
dc.identifier.urihttps://hdl.handle.net/11424/250901
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Densitometry: The Official Journal of the International Society for Clinical Densitometry
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjecttype 2 diabetes
dc.subjectAdvanced glycation end-products
dc.subjectBone mineral density
dc.subjectskin autofluorescence
dc.titleSkin autofluorescence Is associated With low bone mineral density in type 2 diabetic patients
dc.typearticle
dspace.entity.typePublication
local.avesis.id03de3472-25b7-4d87-be74-95a0680bdba2
local.import.packageSS23
local.import.sourcePubMed
local.indexed.atPUBMED
oaire.citation.endPage3
oaire.citation.startPageS1094
oaire.citation.titleJournal of Clinical Densitometry: The Official Journal of the International Society for Clinical Densitometry
relation.isAuthorOfPublication26174ec5-7dca-4038-a7fe-9a43f236fd15
relation.isAuthorOfPublication.latestForDiscovery26174ec5-7dca-4038-a7fe-9a43f236fd15

Files

Collections

Research Outputs