Publication:
Functional and clinical significance of SALL4 in breast cancer

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dc.contributor.authorAKKİPRİK, MUSTAFA
dc.contributor.authorsDirican, Ebubekir; Akkiprik, Mustafa
dc.date.accessioned2022-03-10T15:25:19Z
dc.date.available2022-03-10T15:25:19Z
dc.date.issued2016
dc.description.abstractThe gene encoding Sal-like 4 (Drosophila) (SALL4) is a zinc-finger transcriptional factor and a vertebrate orthologous of the Drosophila gene spalt (sal), which is upregulated in some cancers. SALL4 is expressed in the early developmental stages of Drosophila. Moreover, murine SALL4 plays a vital role in protecting the properties of embryonic stem (ES) cells and guiding the outcome of the primal inner cell mass by interacting with OCT4 and NANOG. SALL4 in ES cells and tumor cells is known as a regulator for controlling cell growth, proliferation, and apoptosis. However, the downstream goals of SALL4 remain largely uncharted. SALL4 expression has been detected in various cancers, including a subset (30 %) of solid tumors, such as breast cancer (BCa), ovarian cancer, gastric cancer, Wilms tumor, and germ cell tumors. A study has reported that SALL4 expression is commonly upregulated in human breast tumors (similar to 86 %) and that overregulation of this gene is often linked to tumor progression. In this review, we provide an overview concerning the role of SALL4 in BCa development and progression. Furthermore, this review may identify some drugs/inhibitors for the development of BCa-specific therapies by targeting SALL4. In the future, SALL4 may be a new biomarker as a diagnostic/therapeutic target of BCa, which would be a new direction in targeted BCa therapy. To our knowledge, this is the first review of the role of SALL4 in BCa development and progression.
dc.identifier.doi10.1007/s13277-016-5150-7
dc.identifier.eissn1423-0380
dc.identifier.issn1010-4283
dc.identifier.pubmed27444278
dc.identifier.urihttps://hdl.handle.net/11424/220205
dc.identifier.wosWOS:000387075400014
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS LTD
dc.relation.ispartofTUMOR BIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSALL4
dc.subjectBreast cancer
dc.subjectES cells
dc.subjectTherapy
dc.subjectOCT4
dc.subjectNANOG
dc.subjectGERM-CELL TUMORS
dc.subjectTRANSCRIPTION FACTOR SALL4
dc.subjectACUTE MYELOID-LEUKEMIA
dc.subjectEARLY EMBRYONIC-DEVELOPMENT
dc.subjectMALIGNANT RHABDOID TUMORS
dc.subjectRENAL-OCULAR SYNDROME
dc.subjectRADIAL RAY SYNDROME
dc.subjectYOLK-SAC TUMORS
dc.subjectOKIHIRO-SYNDROME
dc.subjectHEPATOCELLULAR-CARCINOMA
dc.titleFunctional and clinical significance of SALL4 in breast cancer
dc.typereview
dspace.entity.typePublication
local.avesis.id1f41c6d0-e2a5-4d1f-8c6a-0656f2979213
local.import.packageSS5
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
local.journal.quartileQ2
oaire.citation.endPage11709
oaire.citation.issue9
oaire.citation.startPage11701
oaire.citation.titleTUMOR BIOLOGY
oaire.citation.volume37
relation.isAuthorOfPublication5dfb5478-a529-4c6b-8972-683d96f1c286
relation.isAuthorOfPublication.latestForDiscovery5dfb5478-a529-4c6b-8972-683d96f1c286

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