Publication:
Serum Adipokine Levels in Type 1 Diabetic Patients: Association with Carotid Intima Media Thickness

Simple item page
dc.contributor.authorYAVUZ, DİLEK
dc.contributor.authorsYazici, Dilek; Yavuz, Dilek; Ogunc, Ayliz Velioglu; Sirikci, Onder; Toprak, Ahmet; Deyneli, Oguzhan; Akalin, Sema
dc.date.accessioned2022-03-12T18:05:40Z
dc.date.available2022-03-12T18:05:40Z
dc.date.issued2012
dc.description.abstractBackground: Adipokines are markers of insulin resistance and play a role in the atherosclerotic process. The association of adipokines with the macrovascular complications of type 1 diabetes mellitus (DM) needs to be determined. The aim of this study was to measure serum adiponectin, leptin, and resistin levels in type 1 DM patients and investigate their relationship with carotid intima media thickness (CIMT), a clinical marker of atherosclerosis. Methods: Seventy-five type 1 DM patients and 115 sex and age-matched healthy controls were included in the study. Serum adiponectin, leptin, and resistin levels were measured by the enzyme-linked immunosorbent assay (ELISA method). CIMT was assessed by Doppler ultrasonography Results: Adiponectin levels in diabetics were higher (25.8 +/- 14.8 mg/mL vs. 5.5 +/- 7.3 mg/mL; P<0.0001) and leptin levels were lower than controls (9.4 +/- 6.2 ng/mL vs. 12.8 +/- 8.6 ng/mL; P=0.01). Resistin levels were also higher in the diabetic group compared to controls (2.1 +/- 1.4 ng/mL vs. 1.6 +/- 0.8 ng/mL; P=0.04). Adiponectin was correlated negatively with CIMT (r=-0.24, P=0.03), age (r=-0.30, P=0.02), BMI (r=-0.33, P=0.02), waist-to-hip ratio (WHR) (r=-0.38, P=0.01) and positively with creatinine (r=0.44, P=0.004). Leptin levels were correlated with total cholesterol (r=0.53, P=0.01) and high-density lipoprotein (HDL) (r=0.67, P=0.001). Resistin was correlated with CIMT (r=0.24, P=0.03) and systolic blood pressure (r=0.48, P=0.009). Multivariate analysis revealed resistin and creatinine to be independent predictors of CIMT among adiponectin, leptin, resistin, WHR, glycosylated hemoglobin (HbA1c), and creatinine. Conclusions: Increased adiponectin correlates negatively and resistin positively with CIMT in type 1 diabetic patients, but adjusting for other known predictors reveals only resistin to be associated with subclinical atherosclerosis in this group of patients.
dc.identifier.doi10.1089/met.2011.0052
dc.identifier.issn1540-4196
dc.identifier.pubmed21933002
dc.identifier.urihttps://hdl.handle.net/11424/230742
dc.identifier.wosWOS:000299320500005
dc.language.isoeng
dc.publisherMARY ANN LIEBERT INC
dc.relation.ispartofMETABOLIC SYNDROME AND RELATED DISORDERS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCORONARY-ARTERY-DISEASE
dc.subjectINSULIN-RESISTANCE
dc.subjectPITTSBURGH EPIDEMIOLOGY
dc.subjectMICROVASCULAR COMPLICATIONS
dc.subjectMETABOLIC SYNDROME
dc.subjectADIPONECTIN LEVELS
dc.subjectVASCULAR FUNCTION
dc.subjectMELLITUS
dc.subjectLEPTIN
dc.subjectRISK
dc.titleSerum Adipokine Levels in Type 1 Diabetic Patients: Association with Carotid Intima Media Thickness
dc.typearticle
dspace.entity.typePublication
local.avesis.id36a50cfa-4c3b-4867-beb7-fb28567d3976
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage31
oaire.citation.issue1
oaire.citation.startPage26
oaire.citation.titleMETABOLIC SYNDROME AND RELATED DISORDERS
oaire.citation.volume10
relation.isAuthorOfPublication26174ec5-7dca-4038-a7fe-9a43f236fd15
relation.isAuthorOfPublication.latestForDiscovery26174ec5-7dca-4038-a7fe-9a43f236fd15

Files

Collections

Research Outputs