Publication:
Effects of Midazolam/Low-Dose Ketamine Conscious Intravenous Sedation on Pain, Swelling, and Trismus After Surgical Extraction of Third Molars

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dc.contributor.authorUĞURLU, FAYSAL
dc.contributor.authorsGarip, Hasan; Satilmis, Tulin; Dergin, Guhan; Ugurlu, Faysal; Goker, Kamil
dc.date.accessioned2022-03-12T17:49:33Z
dc.date.available2022-03-12T17:49:33Z
dc.date.issued2011
dc.description.abstractPurpose: To assess the clinical efficacy of midazolam plus low-dose ketamine conscious intravenous sedation on relief from or prevention of postoperative pain, swelling, and trismus after the surgical extraction of third molars. Patients and Methods: Patients admitted for surgical extraction of mandibular third molars (n = 50) were included. All patients received an initial dose of 0.03 mg/kg intravenous midazolam; then patients in the midazolam-placebo (MP) group received 2 mL of a placebo IV, while patients in the midazolam-ketamine (MK) group received 2 mL of a ketamine + saline combination (0.3 mg/kg ketamine + saline) IV. Results: Facial swelling on postoperative days was significantly lower in the MK group than in the MP group (P = .001). Mouth opening on postoperative days was significantly greater in the MK group than in the MP group (P = .001). Pain scores measured on a visual analog scale at 4, 12, and 24 hours after surgery were significantly higher in the MP group than in the MK group (P = .001). Conclusions: Conscious intravenous sedation with midazolam/low-dose ketamine during surgical extraction of third molars can provide the patient with a comfortable procedure and good postoperative analgesia, with less swelling and significantly less trismus. Intravenous low-dose ketamine may be safe and effective in reducing postoperative pain. (C) 2011 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 69:1023-1030, 2011
dc.identifier.doi10.1016/j.joms.2010.05.035
dc.identifier.issn0278-2391
dc.identifier.pubmed21216077
dc.identifier.urihttps://hdl.handle.net/11424/230094
dc.identifier.wosWOS:000289123800019
dc.language.isoeng
dc.publisherW B SAUNDERS CO-ELSEVIER INC
dc.relation.ispartofJOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPOST-TONSILLECTOMY PAIN
dc.subjectPOSTOPERATIVE PAIN
dc.subjectSURGERY
dc.subjectTHERAPY
dc.subjectMETHYLPREDNISOLONE
dc.subjectANALGESIA
dc.subjectEFFICACY
dc.subjectPATIENT
dc.titleEffects of Midazolam/Low-Dose Ketamine Conscious Intravenous Sedation on Pain, Swelling, and Trismus After Surgical Extraction of Third Molars
dc.typearticle
dspace.entity.typePublication
local.avesis.ide9b4a5e5-3b0a-48ac-a0da-c1926217f296
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage1030
oaire.citation.issue4
oaire.citation.startPage1023
oaire.citation.titleJOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
oaire.citation.volume69
relation.isAuthorOfPublicationdf79d838-745a-4d3c-8406-14acb2b84ba9
relation.isAuthorOfPublication.latestForDiscoverydf79d838-745a-4d3c-8406-14acb2b84ba9

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