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Functional and structural changes of the urinary bladder following spinal cord injury; treatment with alpha lipoic acid

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dc.contributor.authorVELİOĞLU ÖĞÜNÇ, AYLİZ
dc.contributor.authorsEkiz, Arif; Ozdemir-Kumral, Zarife Nigar; Ersahin, Mehmet; Tugtepe, Halil; Ogunc, Ayliz Velioglu; Akakin, Dilek; Kiran, Demir; Ozsavci, Derya; Biber, Necat; Hakan, Tayfun; Yegen, Berrak C.; Sener, Goksel; Toklu, Hale Z.
dc.date.accessioned2022-03-12T22:24:10Z
dc.date.available2022-03-12T22:24:10Z
dc.date.issued2017
dc.description.abstractBACKGROUND & AIMAlpha lipoic acid (LA) was shown to exert neuroprotection in trauma-induced spinal cord injury (SCI), which is frequently associated with urinary bladder complaints in patients with SCI. Accordingly, the protective effects of LA on biochemical and histological changes in bladder as well as functional studies were assessed. METHODSWistar albino rats were divided as control, SCI, and LA (50mg/kg/day, ip) treated SCI groups (SCI+LA). The standard weight-drop (100g/cm force at T10) method was used to induce a moderately severe SCI. One week after the injury, neurological examination was performed and the rats were decapitated. Bladder samples were taken for histological examination, functional (isolated tissue bath) studies, and for the measurement of biochemical parameters (malondialdehyde, MDA; gluthathione, GSH; nerve growth factor, NGF; caspase-3, luminol and lucigenin chemiluminescences). RESULTSSCI caused a significant (P<0.001) increase in the detrusor muscle thickness. It increased the contractility responses to carbachol and relaxation responses to papaverine (P<0.05-0.001). There were also significant alterations in MDA, caspase-3, luminol, and lucigenin chemiluminescences with concomitant decreases in NGF and GSH (P<0.05). LA treatment reversed histological and functional (contraction and relaxation responses) changes induced by SCI (P<0.05-0.001), but no significant recovery was observed in the impaired neurological functions. CONCLUSIONThese results indicate that LA have a beneficial effect in improving the bladder tonus via its antioxidant and anti-inflammatory actions following SCI.
dc.identifier.doi10.1002/nau.23083
dc.identifier.eissn1520-6777
dc.identifier.issn0733-2467
dc.identifier.pubmed27490041
dc.identifier.urihttps://hdl.handle.net/11424/234690
dc.identifier.wosWOS:000400147000032
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofNEUROUROLOGY AND URODYNAMICS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbladder
dc.subjectcarbachol
dc.subjectcaspase 3
dc.subjectcontractility
dc.subjectlipoic acid
dc.subjectNGF
dc.subjectNSE
dc.subjectpapaverinee
dc.subjectrelaxation
dc.subjectS100
dc.subjectspinal cord injury
dc.subjecttrauma
dc.subjectOXIDATIVE STRESS
dc.subjectDYSFUNCTION
dc.subjectUROTHELIUM
dc.subjectRAT
dc.titleFunctional and structural changes of the urinary bladder following spinal cord injury; treatment with alpha lipoic acid
dc.typearticle
dspace.entity.typePublication
local.avesis.id8e772b2a-8118-4c84-9704-22c6da2feb2b
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
local.journal.quartileQ1
oaire.citation.endPage1068
oaire.citation.issue4
oaire.citation.startPage1061
oaire.citation.titleNEUROUROLOGY AND URODYNAMICS
oaire.citation.volume36
relation.isAuthorOfPublication13300bf6-ba96-4f87-9868-b0d2c86f572a
relation.isAuthorOfPublication.latestForDiscovery13300bf6-ba96-4f87-9868-b0d2c86f572a

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