Publication:
3D Printing of Gelatine/Alginate/beta-Tricalcium Phosphate Composite Constructs for Bone Tissue Engineering

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dc.contributor.authorOKTAR, FAİK NÜZHET
dc.contributor.authorsKalkandelen, Cevriye; Ulag, Songul; Ozbek, Burak; Eroglu, Gunes O.; Ozerkan, Dilsad; Kuruca, Serap E.; Oktar, Faik N.; Sengor, Mustafa; Gunduz, Oguzhan
dc.date.accessioned2022-03-12T22:39:15Z
dc.date.available2022-03-12T22:39:15Z
dc.date.issued2019
dc.description.abstractBone tissue engineering studies have brought three-dimensional scaffolds into focus that can provide tissue regeneration with designed porosity and strengthened structure. Current research has concentrated on the fabrication of natural and synthetic polymer-based complex structures that closely mimic biological tissues due to their superior biocompatibility and biodegradabilities. Gelatine/Sodium Alginate hydrogels reinforced with different concentrations of beta-Tricalcium Phosphate (TCP) (10, 13, and 15 wt.%) were studied to form 3D bone tissue. Physical, mechanical, chemical, morphological properties and biodegradability of the constructs were investigated. Furthermore, in vitro biological assay with human osteosarcoma cell line (SAOS-2) was performed to determine the biocompatibility of the constructs. It is found that cell viability rates for all constructs were increased and maximum cell viability rate was attained for 20%Gelatine/2%Alginate/10%TCP (wt.). The present work demonstrates that 3D printed Gelatine/Alginate/TCP constructs with porous structures are potential candidates for bone tissue engineering applications.
dc.identifier.doi10.1002/slct.201902878
dc.identifier.issn2365-6549
dc.identifier.urihttps://hdl.handle.net/11424/235790
dc.identifier.wosWOS:000495129900009
dc.language.isoeng
dc.publisherWILEY-V C H VERLAG GMBH
dc.relation.ispartofCHEMISTRYSELECT
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlginate
dc.subjectGelatine
dc.subjectbeta-tricalcium phosphate
dc.subject3D printing
dc.subjectFABRICATION
dc.subjectSCAFFOLDS
dc.title3D Printing of Gelatine/Alginate/beta-Tricalcium Phosphate Composite Constructs for Bone Tissue Engineering
dc.typearticle
dspace.entity.typePublication
local.avesis.id64fb8359-b121-4dc4-bb03-f710349a7198
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages5
local.journal.quartileQ3
oaire.citation.endPage12036
oaire.citation.issue41
oaire.citation.startPage12032
oaire.citation.titleCHEMISTRYSELECT
oaire.citation.volume4
relation.isAuthorOfPublication5ba0a0e0-ebae-43a6-855c-0aabb90021f4
relation.isAuthorOfPublication.latestForDiscovery5ba0a0e0-ebae-43a6-855c-0aabb90021f4

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