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Metabolomics-based profiling with chemometric approach to delineate the bio-pharmaceutical properties of fruit extracts from Ligustrum vulgare L

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dc.contributor.authorŞENKARDEŞ, İSMAİL
dc.contributor.authorsRocchetti, Gabriele; Senizza, Biancamaria; Zengin, Gokhan; Senkardes, Ismail; Sadeer, Nabeelah Bibi; Mahomoodally, Mohamad Fawzi; Lucini, Luigi
dc.date.accessioned2022-03-12T22:38:58Z
dc.date.available2022-03-12T22:38:58Z
dc.date.issued2019
dc.description.abstractLigustrum vulgare L. (Family: Oleaceae) is an evergreen shrub native to North-west Africa, Europe and Western Asia. In the present work, infusion (water), ethyl acetate, methanol and n-hexane extracts of the fruits of L. vulgare L. were studied for their in vitro antioxidant and enzyme inhibitory properties along with their untargeted polyphenolic profile (using an ultra-high-performance liquid chromatography-quadrupole time-of-flight (UHPLC-QTOF) mass spectrometry approach). Untargeted metabolomics coupled to multivariate statistics showed that Ligustrum fruit extracts were very abundant in polyphenols, such as flavonoids, tyrosols and lignans, with ethyl acetate allowing the highest recovery among the extraction solvents tested. The methanolic extract inhibited the highest acetylcholinesterase (AChE), tyrosinase and glucosidase activity (4.23 mg galatamine equivalent (GALAE)/g, 132.85 mg kojic acid equivalent (KAE)/g and 1.94 mmol acarbose equivalent (ACAE)/g respectively) while the ethyl acetate extract inhibited the highest butyrylcholinesterase (BChE) and amylase activity (4.92 mg GALAE/g and 0.73 mmol ACAE/g, respectively). However, the infusion showed the weakest activity against all the enzymes studied. However, the extract showed highest antioxidant property in'the antioxidant assays (except for phosphomolybdenum). The present paper is the first comprehensive report on L. vulgare fruits and thus our findings are of considerable interest to design new bioproducts for the pharmaceutical and cosmeceutical industry in the future.
dc.identifier.doi10.1016/j.indcrop.2019.111635
dc.identifier.eissn1872-633X
dc.identifier.issn0926-6690
dc.identifier.urihttps://hdl.handle.net/11424/235753
dc.identifier.wosWOS:000491621900028
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLigustrum
dc.subjectBioactive compounds
dc.subjectMetabolomics
dc.subjectMultivariate statistics
dc.subjectAntioxidant
dc.subjectEnzyme inhibition
dc.subjectIN-VITRO
dc.subjectANTIOXIDANT ACTIVITY
dc.subjectPHENOLICS
dc.subjectCONSTITUENTS
dc.subjectBERRIES
dc.titleMetabolomics-based profiling with chemometric approach to delineate the bio-pharmaceutical properties of fruit extracts from Ligustrum vulgare L
dc.typearticle
dspace.entity.typePublication
local.avesis.iddb229408-79bd-42a0-acbe-1ab7c502b2b0
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumber111635
local.journal.numberofpages7
local.journal.quartileQ1
oaire.citation.titleINDUSTRIAL CROPS AND PRODUCTS
oaire.citation.volume140
relation.isAuthorOfPublication3e59035c-d7b1-4887-b78c-2a9bc207de05
relation.isAuthorOfPublication.latestForDiscovery3e59035c-d7b1-4887-b78c-2a9bc207de05

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