Publication:
Effects of sodium fluoride on neural tube development in chick embryos

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dc.contributor.authorAKAKIN, DİLEK
dc.contributor.authorsMammadov M., Emon S. T., Akar E., AKAKIN D., Şener D.
dc.date.accessioned2023-10-03T10:29:17Z
dc.date.available2023-10-03T10:29:17Z
dc.date.issued2023-11-01
dc.description.abstractObjective: Various environmental factors encountered in daily life are associated with the development of neural tube defects. This study aims to investigate the effects of fluoride on neural tube development in chick embryos. Methods: A total of 60 specific pathogen-free, fertile, zero-day Leghorn-type eggs were used in the study. Group 1 was the control group, in which only saline was administered. Group 2 was the low-dose group, in which 0.003 mg of fluoride was administered, and Group 3 was the high-dose group, in which 0.006 mg of fluoride was administered. After 72 h of incubation, the embryonic disc was evaluated microscopically. Results: In the control group, the surface ectoderm of all sections was intact, the neural tube was closed, and the neuroepithelium, the basement membrane surrounding the neuroepithelium, the somites, and the notochord displayed standard structure. Neural tube defects were observed in 3 of the chick embryos, that was given low-dose fluoride. In Group 3, which was administered high doses of fluoride, neural tube defects were observed in 4 embryos. It was observed that the development of neural tube defects was no statistically significantly higher in low and high-dose fluoride group compared to the control group. Conclusion: Low and high-dose fluoride exposure was associated with developing neural tube defects, but there was no statisticaly significance.
dc.identifier.citationMammadov M., Emon S. T., Akar E., AKAKIN D., Şener D., "Effects of sodium fluoride on neural tube development in chick embryos", Neurochirurgie, cilt.69, sa.6, 2023
dc.identifier.doi10.1016/j.neuchi.2023.101502
dc.identifier.issn0028-3770
dc.identifier.issue6
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85171654352&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/294228
dc.identifier.volume69
dc.language.isoeng
dc.relation.ispartofNeurochirurgie
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.subjectCerrahi Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectNeurology
dc.subjectSurgery Medicine Sciences
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectCERRAHİ
dc.subjectKLİNİK NÖROLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectSURGERY
dc.subjectCLINICAL NEUROLOGY
dc.subjectCerrahi
dc.subjectNöroloji (klinik)
dc.subjectSurgery
dc.subjectNeurology (clinical)
dc.subjectEarly chick embryo
dc.subjectFluoride
dc.subjectNeural tube defect
dc.subjectSodium fluori
dc.titleEffects of sodium fluoride on neural tube development in chick embryos
dc.typearticle
dspace.entity.typePublication
local.avesis.id2763b436-825e-4369-a62a-a8870803e0ab
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationc97c0ebf-ffce-4b27-a933-941a53767b0d
relation.isAuthorOfPublication.latestForDiscoveryc97c0ebf-ffce-4b27-a933-941a53767b0d

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