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Incidence of SARS-CoV-2 in people with cystic fibrosis in Europe between February and June 2020

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dc.contributor.authorGÖKDEMİR, YASEMİN
dc.contributor.authorsNaehrlich, Lutz; Orenti, Annalisa; Dunlevy, Fiona; Kasmi, Irena; Harutyunyan, Satenik; Pfleger, Andreas; Keegan, Svetlana; Daneau, Geraldine; Petrova, Guergana; Tjesic-Drinkovic, Duska; Yiallouros, Panayioti; Bilkova, Alena; Olesen, Hanne Vebert; Burgel, Pierre-Regis; Parulava, Tsitsino; Diamantea, Filia; Parniczky, Andrea; McKone, Edward F.; Mei-Zahav, Meir; Salvatore, Marco; Colombo, Carla; Aleksejeva, Elina; Malakauskas, Kestutis; Schlesser, Marc; Fustik, Stojka; Turcu, Oxana; Zomer-van Ommen, Domenique; Wathne, Anita Senstad; Wozniacki, Lukasz; Pereira, Luisa; Pop, Liviu; Kashirskaya, Nataliya; Rodic, Milan; Kayserova, Hana; Krivecs, Uro; Mondejar-Lopez, Pedro; de Monsterol, Isabelle; Dogru, Deniz; Makukh, Halyn; Cosgriff, Rebecca; van Koningsbruggen-Rietschel, Silke; Jung, Andreas; Bobrovnichy, Vladimir; Bambir, Ivan; Vukic, Andrea Dugac; Drevinek, Pavel; Macek, Milan, Jr.; Corvol, Harriet; Lemonnier-Videau, Lydie; Hatziagorou, Elpis; Fletcher, Godfrey; Padoan, Rita; Gulmans, Vincent; Bakkeheim, Egil; Kondratyeva, Elena; Amelina, Elena; Zhekaite, Elena; Simonova, Olga; Pastor-Vivero, Maria Dolores; Lindblad, Anders; Gokdemir, Yasemin; Pekcan, Sevgi; Brownlee, Keith; McClenaghan, Elliot; Carr, Siobhan; Lammertyn, Elise; Zolin, Anna; Fox, Alice; Krasnyk, Marko; Van Rens, Jacqui
dc.date.accessioned2022-03-14T09:59:14Z
dc.date.available2022-03-14T09:59:14Z
dc.date.issued2021-07
dc.description.abstractBackground: Viral infections can cause significant morbidity in cystic fibrosis (CF). The current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic could therefore have a serious impact on the health of people with CF (pwCF). Methods: We used the 38-country European Cystic Fibrosis Society Patient Registry (ECFSPR) to collect case data about pwCF and SARS-CoV-2 infection. Results: Up to 30 June 2020, 16 countries reported 130 SARS-CoV-2 cases in people with CF, yielding an incidence of 2.70/10 0 0 pwCF. Incidence was higher in lung-transplanted patients (n = 23) versus non transplanted patients (n = 107) (8.43 versus 2.36 cases/10 0 0). Incidence was higher in pwCF versus the age-matched general population in the age groups < 15, 15-24, and 25-49 years (p < 0.001), with similar trends for pwCF with and without lung transplant. Compared to the general population, pwCF (regardless of transplantation status) had significantly higher rates of admission to hospital for all age groups with available data, and higher rates of intensive care, although not statistically significant. Most pwCF recovered (96.2%), however 5 died, of whom 3 were lung transplant recipients. The case fatality rate for pwCF (3.85%, 95% CI: 1.26-8.75) was non-significantly lower than that of the general population (7.46%; p = 0.133). Conclusions: SARS-CoV-2 infection can result in severe illness and death for pwCF, even for younger patients and especially for lung transplant recipients. PwCF should continue to shield from infection and should be prioritized for vaccination. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
dc.identifier.doi10.1016/j.jcf.2021.03.017
dc.identifier.eissn1873-5010
dc.identifier.issn1569-1993
dc.identifier.pubmed34016559
dc.identifier.urihttps://hdl.handle.net/11424/243828
dc.identifier.wosWOS:000688499300004
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofJOURNAL OF CYSTIC FIBROSIS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCystic fibrosis
dc.subjectCovid-19
dc.subjectSARS-CoV-2
dc.subjectEurope
dc.subjectIncidence
dc.subjectEpidemiology
dc.subjectIMPACT
dc.titleIncidence of SARS-CoV-2 in people with cystic fibrosis in Europe between February and June 2020
dc.typearticle
dspace.entity.typePublication
local.avesis.id40d949b2-9382-4104-9a40-0016e96033fc
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages12
oaire.citation.endPage577
oaire.citation.issue4
oaire.citation.startPage566
oaire.citation.titleJOURNAL OF CYSTIC FIBROSIS
oaire.citation.volume20
relation.isAuthorOfPublication33d10238-6955-4a99-8e91-79975cc5200e
relation.isAuthorOfPublication.latestForDiscovery33d10238-6955-4a99-8e91-79975cc5200e

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