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Schizosaccharomyces pombe and its Ni(II)-insensitive mutant GA1 in Ni(II) uptake from aqueous solutions: a biodynamic model

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dc.contributor.authorSAYAR, AHMET ALP
dc.contributor.authorsSayar, Nihat Alpagu; Durmaz-Sam, Selcen; Kazan, Dilek; Sayar, Ahmet Alp
dc.date.accessioned2022-03-13T12:44:30Z
dc.date.available2022-03-13T12:44:30Z
dc.date.issued2014
dc.description.abstractIn the present study, Ni(II) uptake from aqueous solution by living cells of the Schizosaccharomyces pombe haploid 972 with h (-) mating type and a Ni(II)-insensitive mutant GA1 derived from 972 was investigated at various initial glucose and Ni(II) concentrations. A biodynamic model was developed to predict the unsteady and steady-state phases of the uptake process. Gompertz growth and uptake process parameters were optimized to predict the maximum growth rate mu (m) and the process metric C (r), the remaining Ni(II) content in the aqueous solution. The simulated overall metal uptake values were found to be in acceptable agreement with experimental results. The model validation was done through regression statistics and uncertainty and sensitivity analyses. To gain insight into the phenomenon of Ni(II) uptake by wild-type and mutant S. pombe, probable active and passive metal transport mechanisms in yeast cells were discussed in view of the simulation results. The present work revealed the potential of mutant GA1 to remove Ni(II) cations from aqueous media. The results obtained provided new insights for understanding the combined effect of biosorption and bioaccumulation processes for metal removal and offered a possibility for the use of growing mutant S. pombe cell in bioremediation.
dc.identifier.doi10.1007/s00253-014-5740-5
dc.identifier.eissn1432-0614
dc.identifier.issn0175-7598
dc.identifier.pubmed24752843
dc.identifier.urihttps://hdl.handle.net/11424/237552
dc.identifier.wosWOS:000339880300029
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofAPPLIED MICROBIOLOGY AND BIOTECHNOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSchizosaccharomyces pombe
dc.subjectBioaccumulation
dc.subjectBioremediation
dc.subjectMathematical modeling
dc.subjectNickel
dc.subjectHEAVY-METALS
dc.subjectNICKEL(II) IONS
dc.subjectNI II
dc.subjectBIOSORPTION
dc.subjectYEAST
dc.subjectBIOACCUMULATION
dc.subjectREMOVAL
dc.subjectBIOMASS
dc.subjectCOPPER(II)
dc.subjectCR(III)
dc.titleSchizosaccharomyces pombe and its Ni(II)-insensitive mutant GA1 in Ni(II) uptake from aqueous solutions: a biodynamic model
dc.typearticle
dspace.entity.typePublication
local.avesis.id83775ee0-9bab-45ae-8906-5f3fda3b2084
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages11
oaire.citation.endPage6869
oaire.citation.issue15
oaire.citation.startPage6859
oaire.citation.titleAPPLIED MICROBIOLOGY AND BIOTECHNOLOGY
oaire.citation.volume98
relation.isAuthorOfPublication279446ed-107e-4bcc-b5a2-21a8f8fbc72c
relation.isAuthorOfPublication.latestForDiscovery279446ed-107e-4bcc-b5a2-21a8f8fbc72c

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