Publication:
Neutrophil gelatinase associated lipocalin in predicting postoperative acute kidney injury in elderly

Simple item page
dc.contributor.authorORHON ERGÜN, MELİHA
dc.contributor.authorsOrhon Ergun, Meliha; Zengin, Seniyye Ulgen; Mustafayeva, Aynur; Umuroglu, Tumay
dc.date.accessioned2022-03-12T22:55:01Z
dc.date.available2022-03-12T22:55:01Z
dc.description.abstractBackground Elderly patients are at increased risk of developing acute kidney injury (AKI) following major surgery and rapid diagnosis is essential. Aim This study aimed to examine the potential utility of plasma neutrophil gelatinase associated lipocalin levels in early prediction of AKI in geriatric patients undergoing laparotomic oncological surgery. Methods This prospective single-center cohort study included 60 geriatric patients (>= 65 years of age) that underwent major oncologic surgery with laparotomy. Perioperative measurements of plasma creatinine, blood urinary nitrogen, plasma lactate, urine output, and neutrophil gelatinase associated lipocalin (NGAL) were made. Patients were followed for AKI development, which is the primary outcome measure, and predictive role of NGAL was investigated. Results At 48 h follow-up, AKI developed in 13 patients (21.7%). Significant differences in creatinine (p < 0.001), NGAL (p < 0.001), and urine output levels (p = 0.001) were evident over time between the two groups. High NGAL measurements at 6 and 24 h after surgery seem to be highly predictive of AKI development. At 6 h, a plasma NGAL level greater than 71.8 ng/mL has a sensitivity and specificity of 85% and 81% in predicting subsequent AKI development. Conclusions Plasma NGAL levels seem to represent an early and reliable marker for AKI in elderly patients undergoing laparotomic surgery with the potential to allow early diagnosis and prevent further renal deterioration. Further confirmatory studies are warranted. Trial registration The study was registered to ClinicalTrials.gov (number, NCT05030727). Implication statement Elderly patients are at increased risk of postoperative acute kidney injury (AKI). This study shows that plasma neutrophil gelatinase associated lipocalin is a helpful marker to predict AKI in elderly patients undergoing laparotomic major surgery, which will allow early diagnosis and prevent further renal deterioration in this vulnerable patient group.
dc.identifier.doi10.1007/s11845-021-02865-z
dc.identifier.eissn1863-4362
dc.identifier.issn0021-1265
dc.identifier.pubmed34822023
dc.identifier.urihttps://hdl.handle.net/11424/236615
dc.identifier.wosWOS:000722542600004
dc.language.isoeng
dc.publisherSPRINGER LONDON LTD
dc.relation.ispartofIRISH JOURNAL OF MEDICAL SCIENCE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAbdominal surgery
dc.subjectAcute kidney injury (AKI)
dc.subjectElderly
dc.subjectLaparotomy
dc.subjectOncologic surgery
dc.subjectPlasma neutrophil gelatinase associated lipocalin (pNGAL)
dc.subjectCARDIOPULMONARY BYPASS
dc.subjectCYSTATIN C
dc.subjectBIOMARKER
dc.subjectOUTCOMES
dc.titleNeutrophil gelatinase associated lipocalin in predicting postoperative acute kidney injury in elderly
dc.typearticle
dspace.entity.typePublication
local.avesis.id1a19fa5a-2af0-42c0-9231-4c61f006b60f
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.titleIRISH JOURNAL OF MEDICAL SCIENCE
relation.isAuthorOfPublication85cfab7c-6b35-4062-9d3b-5bf009e44c9b
relation.isAuthorOfPublication.latestForDiscovery85cfab7c-6b35-4062-9d3b-5bf009e44c9b

Files

Collections

Research Outputs