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Effects of Different Concentrations of Injectable Collagenase Enzyme on Capsular Tissue Around Silicone Implants: A Preliminary Experimental Study for the Development of a New Treatment Strategy

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dc.contributor.authorFİLİNTE, DENİZ
dc.contributor.authorsYesiloglu, Nebil; Temiz, Gokhan; Sarici, Murat; Yildiz, Kemalettin; Sirinoglu, Hakan; Guvercin, Emre; Akpinar, Ali Cem; Filinte, Gaye Taylan; Filinte, Deniz
dc.date.accessioned2022-03-12T20:28:46Z
dc.date.available2022-03-12T20:28:46Z
dc.date.issued2016
dc.description.abstractIn recent studies, collagen organization was blamed for the formation of capsular contracture which is still a challenging problem after silicone implant-based breast operations. In this study, effects of different concentrations of collagenase enzyme derived from Clostridium histolyticum on the capsular tissue formation around the silicone implants were investigated. The injectable form of collagenase has a routine clinical use in the treatment of both Dupuytren's and Peyronie's diseases. Thirty-two Wistar albino rats were randomized into four groups. A 2 x 1 x 0.3-cm-sized silicone block was inserted inside a dorsal subcutaneous pocket in all groups. After 2 months of insertion, capsule thicknesses around the implants were detected under ultrasonography. This was followed by injection of isotonic saline, 150, 300, and 600 IU in Gr-1, 2, 3, and 4, respectively. All the animals were sacrificed at the end of the first week for histologic sampling to determine fibroblast proliferation, vessel density of the tissue, necrosis, edema, inflammation, and capsule thickness. All the data were statistically analyzed using Kruskal-Wallis and Mann-Whitney U tests and compared for significance of the results. There was no significant difference in terms of capsule thinning between the 300 and 600 IU groups but in both groups thinning was significantly higher than the sham group. In the 150 IU group there was no significant thinning as compared to the sham group (p > 0.05). However, complications such as skin necrosis, infection, and seroma formation were seen only in the 600 IU injection group. The optimal safe and effective dose of the enzyme was accepted as 300 IU. The 300 IU injection provided up to 89 % thinning in the capsule tissue. There was thinning of the collagen bundles parallel to capsule thickness. In the 600 IU group, micro-pores were encountered at the thinnest points. However, the late results and recurrence rates of capsular contracture were not included in this study; collagenase seemed effective for the reduction of capsular tissue around the implants. This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors http://www.springer.com/00266.
dc.identifier.doi10.1007/s00266-015-0600-y
dc.identifier.eissn1432-5241
dc.identifier.issn0364-216X
dc.identifier.pubmed26715576
dc.identifier.urihttps://hdl.handle.net/11424/233973
dc.identifier.wosWOS:000370239600021
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofAESTHETIC PLASTIC SURGERY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectClostridium histolyticum collagenase
dc.subjectCapsular contracture
dc.subjectSilicone implants
dc.subjectBreast implants
dc.subjectBREAST
dc.subjectCONTRACTURE
dc.subjectDISEASE
dc.subjectINFECTION
dc.subjectINJECTION
dc.subjectEFFICACY
dc.subjectOUTCOMES
dc.subjectSURFACE
dc.subjectSAFETY
dc.subjectMODEL
dc.titleEffects of Different Concentrations of Injectable Collagenase Enzyme on Capsular Tissue Around Silicone Implants: A Preliminary Experimental Study for the Development of a New Treatment Strategy
dc.typearticle
dspace.entity.typePublication
local.avesis.id9d91d7ac-4e9a-4c64-ae25-6ff2d88f53d0
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
local.journal.quartileQ3
oaire.citation.endPage173
oaire.citation.issue1
oaire.citation.startPage164
oaire.citation.titleAESTHETIC PLASTIC SURGERY
oaire.citation.volume40
relation.isAuthorOfPublicationa8c8e3b3-0957-4056-a8f4-03be36b426b4
relation.isAuthorOfPublication.latestForDiscoverya8c8e3b3-0957-4056-a8f4-03be36b426b4

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