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Dual spinneret electrospun polyurethane/pva-gelatin nanofibrous scaffolds containing cinnamon essential oil and nanoceria for chronic diabetic wound healing: preparation, physicochemical characterization and in-vitro evaluation

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dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorsHussein M. A. M., Gunduz O., Sahin A., Grinholc M., El-Sherbiny I. M., Megahed M.
dc.date.accessioned2023-04-13T06:30:44Z
dc.date.available2023-04-13T06:30:44Z
dc.date.issued2022-04-01
dc.description.abstract© 2022 by the authors. Licensee MDPI, Basel, Switzerland.In this study, a dual spinneret electrospinning technique was applied to fabricate a series of polyurethane (PU) and polyvinyl alcohol–gelatin (PVA/Gel) nanofibrous scaffolds. The study aims to enhance the properties of PU/PVA-Gel NFs loaded with a low dose of nanoceria through the incorporation of cinnamon essential oil (CEO). The as-prepared nCeO2 were embedded into the PVA/Gel nanofibrous layer, where the cinnamon essential oil (CEO) was incorporated into the PU nanofibrous layer. The morphology, thermal stability, mechanical properties, and chemical composition of the produced NF mats were investigated by STEM, DSC, and FTIR. The obtained results showed improvement in the mechanical, and thermal stability of the dual-fiber scaffolds by adding CEO along with nanoceria. The cytotoxicity evaluation revealed that the incorporation of CEO to PU/PVA-Gel loaded with a low dose of nanoceria could enhance the cell population compared to using pure PU/PVA-Gel NFs. Moreover, the presence of CEO could inhibit the growth rate of S. aureus more than E. coli. To our knowledge, this is the first time such nanofibrous membranes composed of PU and PVA-Gel have been produced. The first time was to load the nanofibrous membranes with both CEO and nCeO2. The obtained results indicate that the proposed PU/PVA-Gel NFs represent promising platforms with CEO and nCeO2 for effectively managing diabetic wounds.
dc.identifier.citationHussein M. A. M., Gunduz O., Sahin A., Grinholc M., El-Sherbiny I. M., Megahed M., "Dual Spinneret Electrospun Polyurethane/PVA-Gelatin Nanofibrous Scaffolds Containing Cinnamon Essential Oil and Nanoceria for Chronic Diabetic Wound Healing: Preparation, Physicochemical Characterization and In-Vitro Evaluation", Molecules, cilt.27, sa.7, 2022
dc.identifier.doi10.3390/molecules27072146
dc.identifier.issn1420-3049
dc.identifier.issue7
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85127480956&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/288659
dc.identifier.volume27
dc.language.isoeng
dc.relation.ispartofMolecules
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectKimya
dc.subjectBiyokimya
dc.subjectAlkoloidler
dc.subjectTemel Bilimler
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectChemistry
dc.subjectBiochemistry
dc.subjectAlcaloides
dc.subjectNatural Sciences
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKİMYA, MULTİDİSİPLİNER
dc.subjectTemel Bilimler (SCI)
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectLife Sciences (LIFE)
dc.subjectCHEMISTRY, MULTIDISCIPLINARY
dc.subjectCHEMISTRY
dc.subjectNatural Sciences (SCI)
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectClinical Biochemistry
dc.subjectCancer Research
dc.subjectMolecular Biology
dc.subjectDrug Discovery
dc.subjectAging
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectStructural Biology
dc.subjectChemistry (miscellaneous)
dc.subjectGeneral Chemistry
dc.subjectPhysical Sciences
dc.subjectnanoceria
dc.subjectdual spinneret electrospinning
dc.subjectPU
dc.subjectPVA-gelatin-based nanofibrous scaffolds
dc.subjectdiabetic wound healing
dc.subjectANTIMICROBIAL PROPERTIES
dc.subjectANTIBACTERIAL ACTIVITY
dc.subjectCOMPOSITE NANOFIBERS
dc.subjectNANOPARTICLES
dc.subjectOXIDE
dc.subjectFILMS
dc.subjectMECHANISM
dc.subjectMEMBRANES
dc.subjectCOMBINATION
dc.subjectDRESSINGS
dc.subjectPU/PVA-gelatin-based nanofibrous scaffolds
dc.subjectnanoceria
dc.subjectdual spinneret electrospinning
dc.subjectPU/PVA-gelatin-based nanofibrous scaffolds
dc.subjectdiabetic wound healing
dc.titleDual spinneret electrospun polyurethane/pva-gelatin nanofibrous scaffolds containing cinnamon essential oil and nanoceria for chronic diabetic wound healing: preparation, physicochemical characterization and in-vitro evaluation
dc.typearticle
dspace.entity.typePublication
local.avesis.id3550944a-74f8-47ac-ba79-98cd0912db00
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublicationf11e8073-bf2f-485f-9bdf-5b3a2a0bdc1f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

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