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Hyperandrogenism-related metabolic changes in drug-naïve transmen compared to cisgender women: a case-controlled study

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dc.contributor.authorEREL, PINAR
dc.contributor.authorELBASAN, ONUR
dc.contributor.authorYORGUNER, NEŞE
dc.contributor.authorİMRE, EREN
dc.contributor.authorÜSTAY, ÖZLEM
dc.contributor.authorsEREL P., ELBASAN O., Yorguner N., İmre E., ÜSTAY Ö.
dc.date.accessioned2023-12-04T07:09:37Z
dc.date.available2023-12-04T07:09:37Z
dc.date.issued2023-01-01
dc.description.abstractIntroduction: The aetiology of gender dysphoria is still unclear. Although prior studies have shown that trans men have higher androgen levels than cisgender women, they all concluded unselected populations. Our reason for performing this study is to evaluate trans men’s hormone profile and metabolic status to compare with cisgender women in a more selected population. This is the first case-controlled study to compare anthropometric, metabolic, and endocrinological parameters of drug-naïve trans men with those of cisgender women. Material and methods: We designed this study as a single-centre observational cohort study. We included 70 drug-naïve trans men, and the control group comprised 34 healthy cisgender women. We measured and compared hormone profiles and metabolic parameters in the 2 groups. Results: Of the 70 trans men individuals, 16 (22.85%) met the Rotterdam criteria and were diagnosed with polycystic ovary syndrome (PCOS); 4 individuals in the control group met the criteria (11.7%). Although we matched body mass index in the groups, total testosterone, free androgen index, androstenedione, 17 hydroxyprogesterone, muscle strength, triglyceride, and homeostatic model assessment of insulin resistance levels were significantly higher in the trans men than in the cisgender women (p < 0.05). Even after were excluded PCOS patients, hyperandrogenaemia was apparent in the trans men. Conclusion: Our study showed that trans men have clearly higher androgen levels, which may have been the reason for metabolic changes compared to cisgender women. However, the main reason for hyperandrogenism in drug-naïve trans men is still not known, and more comprehensive studies are needed.
dc.identifier.citationEREL P., ELBASAN O., Yorguner N., İmre E., ÜSTAY Ö., "Hyperandrogenism-related metabolic changes in drug-naïve transmen compared to cisgender women: a case-controlled study", Endokrynologia Polska, cilt.74, sa.4, ss.398-403, 2023
dc.identifier.doi10.5603/ep.a2023.0052
dc.identifier.endpage403
dc.identifier.issn0423-104X
dc.identifier.issue4
dc.identifier.startpage398
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85176604081&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/295297
dc.identifier.volume74
dc.language.isoeng
dc.relation.ispartofEndokrynologia Polska
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectEndocrinology and Metabolic Diseases
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectENDOCRINOLOGY & METABOLISM
dc.subjectEndokrinoloji, Diyabet ve Metabolizma
dc.subjectEndokrinoloji
dc.subjectYaşam Bilimleri
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectEndocrinology
dc.subjectLife Sciences
dc.subjectandrogen
dc.subjectcisgender women
dc.subjectmetabolic syndrome
dc.subjecttrans men
dc.titleHyperandrogenism-related metabolic changes in drug-naïve transmen compared to cisgender women: a case-controlled study
dc.typearticle
dspace.entity.typePublication
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local.indexed.atPUBMED
local.indexed.atSCOPUS
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relation.isAuthorOfPublication.latestForDiscovery7499614e-1a5f-4d03-b07e-d9d208d3c90e

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