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Synergistic Induction of Apoptosis by Quercetin and Curcumin in Chronic Myeloid Leukemia (K562) Cells: II. Signal Transduction Pathways Involved

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dc.contributor.authorYALÇIN, AHMET SUHA
dc.contributor.authorsAltundag, Ergul Mutlu; Yilmaz, Ayse Mine; Serdar, Belgin Sert; Jannuzzi, Ayse Tarbin; Kocturk, Semra; Yalcin, A. Suha
dc.date.accessioned2022-03-12T22:54:43Z
dc.date.available2022-03-12T22:54:43Z
dc.date.issued2021
dc.description.abstractFlavonoids are phenolic substances with chemo-preventive and chemotherapeutic properties. They are widely found in fruits and vegetables. The polyphenols quercetin and curcumin have antioxidant, anti-inflammatory, anti-carcinogenic, and pro-apoptotic properties. They were successfully used against different human cancers, especially chronic myeloid leukemia cancer cells. We have previously investigated anti-proliferative and apoptotic effects of quercetin and curcumin combination in K562 cells. Our data showed that they had beneficial synergistic effects. Based on these findings, we aimed to clarify signaling pathways involved in synergistic combination treatment with quercetin and curcumin in these cells. Proteins were investigated by Western blotting and by confocal microscopy. Changes in several genes in 10 different pathways related to cell proliferation, apoptosis, cell cycle, inflammation, hypoxia and oxidative stress were observed. Combination of quercetin and curcumin was effective on genes that were particularly related to p53, NF-kappa B and TGF-alpha pathways. Down-regulatory (CDKN1B, AKT1, IFN-gamma) and up-regulatory (BTG2, CDKN1A, FAS) effects on genes and related protein expressions may provide a multi-targeted therapy potential for chronic myeloid leukemia cancer cells without affecting healthy cells.
dc.identifier.doi10.1080/01635581.2020.1767167
dc.identifier.eissn1532-7914
dc.identifier.issn0163-5581
dc.identifier.pubmed32420759
dc.identifier.urihttps://hdl.handle.net/11424/236483
dc.identifier.wosWOS:000535119200001
dc.language.isoeng
dc.publisherROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
dc.relation.ispartofNUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectKAPPA-B
dc.subjectCYCLE
dc.subjectDEATH
dc.subjectBIOAVAILABILITY
dc.subjectPRODUCTS
dc.subjectTARGETS
dc.subjectBTG2
dc.titleSynergistic Induction of Apoptosis by Quercetin and Curcumin in Chronic Myeloid Leukemia (K562) Cells: II. Signal Transduction Pathways Involved
dc.typearticle
dspace.entity.typePublication
local.avesis.idb667e043-f67e-4fd7-aaae-4882ae0ca815
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
local.journal.quartileQ3
oaire.citation.endPage712
oaire.citation.issue4
oaire.citation.startPage703
oaire.citation.titleNUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
oaire.citation.volume73
relation.isAuthorOfPublication7a2bc583-aab6-43e7-9cc3-0d7a60773409
relation.isAuthorOfPublication.latestForDiscovery7a2bc583-aab6-43e7-9cc3-0d7a60773409

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