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Oxidative organ damage in a rat model of thermal injury: the effect of cyclosporin A

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsGürbüz, V.; Corak, A.; Yeğen, B. C.; Kurtel, H.; Alican, I.
dc.date.accessioned2022-03-15T11:23:03Z
dc.date.available2022-03-15T11:23:03Z
dc.date.issued1997
dc.description.abstractAnimal models of thermal trauma implicate oxygen radicals as a causative agent in local wound response, development of burn shock and distant organ injury. It has been proposed that the source of reactive oxygen metabolites could be neutrophils sequestered in systemic organs as a result of the systemic inflammatory reaction to a local burn insult. Recent studies have suggested that cyclosporin A (CsA), a potent immunosuppressive drug, may have effects on neutrophils by modulating the rate of their accumulation during acute inflammatory reactions. This study aimed to assess the role of neutrophils in the early and late phases of burn injury in rats with second-degree skin burn. We also aimed to determine whether CsA has protective effects on organs remote from the thermal injury. The results demonstrate that there is significant neutrophil accumulation in the gastric mucosa, liver and lung tissues during the early phase of a burn injury and that CsA failed to protect these organs. In conclusion, the data of this study suggest that neutrophil accumulation in liver, lung and gastric mucosa following burn injury may be involved in the pathogenesis of remote organ damage. The results also indicate that CsA failed to reduce the severity of damage in these organs, probably due to its own toxic effects.
dc.identifier.doi10.1016/s0305-4179(96)00072-1
dc.identifier.issn0305-4179
dc.identifier.pubmedPMID: 9115608
dc.identifier.urihttps://hdl.handle.net/11424/249897
dc.language.isoeng
dc.relation.ispartofBurns: Journal of the International Society for Burn Injuries
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFemale
dc.subjectImmunosuppressive Agents
dc.subjectAnimals
dc.subjectMale
dc.subjectRats
dc.subjectDisease Models, Animal
dc.subjectRats, Wistar
dc.subjectAnalysis of Variance
dc.subjectGlutathione
dc.subjectOxidative Stress
dc.subjectPeroxidase
dc.subjectBurns
dc.subjectNeutrophils
dc.subjectFree Radicals
dc.subjectLipid Peroxides
dc.subjectCyclosporine
dc.subjectCulture Techniques
dc.titleOxidative organ damage in a rat model of thermal injury: the effect of cyclosporin A
dc.typearticle
dspace.entity.typePublication
local.avesis.id8ea3d7c2-a0d1-4ccd-a991-89f90e69876a
local.import.packageSS23
local.import.sourcePubMed
local.indexed.atPUBMED
oaire.citation.endPage42
oaire.citation.startPage37
oaire.citation.titleBurns: Journal of the International Society for Burn Injuries
oaire.citation.volume1
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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