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Curcumin displays enhanced solubility and antibacterial activities when complexed with the cell penetrating peptide pVEC

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dc.contributor.authorSARIYAR AKBULUT, BERNA
dc.contributor.authorsKoleoglu E., Acar T., DERMAN S., SARIYAR AKBULUT B.
dc.date.accessioned2023-06-19T07:51:53Z
dc.date.available2023-06-19T07:51:53Z
dc.date.issued2022-06-01
dc.description.abstractCurcumin is among phytochemicals with increasing popularity; unfortunately, its therapeutic potential is restricted due to poor water solubility and bioavailability. The current work undertakes the effort to improve the therapeutic potential of curcumin by complexing it with a cell penetrating peptide using copper ions. A mononuclear complex was synthesized from copper(II) acetate and curcumin. Then this complex was conjugated to the cell penetrating peptide, pVEC. The structural characterization of the complexes was achieved using UV-Vis and Fourier transform infrared spectroscopies. Dynamic and electrophoretic light scattering measurements have confirmed the complexation of curcumin with the peptide to form nanoparticles. Both solubility and kinetic stability of curcumin greatly improved upon complex formation with pVEC through copper ions. Then the antibacterial activity of curcumin in the complex was tested. The amount of curcumin in the minimum inhibitory concentration was similar to 30, similar to 8, and similar to 15 fold lower, respectively for Escherichia coli, Bacillus subtilis, and Staphylococcus aureus when complexed with pVEC; however, this improvement was specifically noteworthy for the gram-negative E. coli since the contribution of pVEC in the complex to the observed activity was negligible in this bacterium. With enhanced solubility and stability, metallo curcumin conjugated pVEC complex possesses potential for different therapeutic applications.
dc.identifier.citationKoleoglu E., Acar T., DERMAN S., SARIYAR AKBULUT B., "Curcumin Displays Enhanced Solubility and Antibacterial Activities When Complexed with the Cell Penetrating Peptide pVEC", INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, cilt.28, sa.4, 2022
dc.identifier.doi10.1007/s10989-022-10415-z
dc.identifier.issn1573-3149
dc.identifier.issue4
dc.identifier.urihttps://link.springer.com/article/10.1007/s10989-022-10415-z
dc.identifier.urihttps://hdl.handle.net/11424/290387
dc.identifier.volume28
dc.language.isoeng
dc.relation.ispartofINTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectNatural Sciences
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectLife Sciences (LIFE)
dc.subjectBiyokimya, Genetik ve Moleküler Biyoloji (çeşitli)
dc.subjectKlinik Biyokimya
dc.subjectKanser Araştırmaları
dc.subjectMoleküler Biyoloji
dc.subjectİlaç Keşfi
dc.subjectYaşlanma
dc.subjectGenel Biyokimya, Genetik ve Moleküler Biyoloji
dc.subjectBiyokimya
dc.subjectYapısal Biyoloji
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectClinical Biochemistry
dc.subjectCancer Research
dc.subjectMolecular Biology
dc.subjectDrug Discovery
dc.subjectAging
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectBiochemistry
dc.subjectStructural Biology
dc.subjectCurcumin
dc.subjectCell penetrating peptide
dc.subjectCopper
dc.subjectSolubility
dc.subjectStability
dc.subjectAntimicrobial activity
dc.subjectIN-VITRO
dc.subjectAQUEOUS SOLUBILITY
dc.subjectNATURAL-PRODUCTS
dc.subjectMETAL-COMPLEXES
dc.subjectNANOPARTICLES
dc.subjectSTABILITY
dc.subjectDEGRADATION
dc.subjectACID
dc.subjectDRUG
dc.subjectENCAPSULATION
dc.subjectCurcumin
dc.subjectCell penetrating peptide
dc.subjectCopper
dc.subjectSolubility
dc.subjectStability
dc.subjectAntimicrobial activity
dc.titleCurcumin displays enhanced solubility and antibacterial activities when complexed with the cell penetrating peptide pVEC
dc.typearticle
dspace.entity.typePublication
local.avesis.idc8536d84-2eb4-4902-9056-35e35f0c2792
local.indexed.atWOS
local.indexed.atSCOPUS
relation.isAuthorOfPublicationa9f127d3-8332-44dd-a532-34f3ef20bdb5
relation.isAuthorOfPublication.latestForDiscoverya9f127d3-8332-44dd-a532-34f3ef20bdb5

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