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A Comparison Study of Fiber Diameter's Effect on Characteristic Features of Donepezil/Curcumin-Loaded Polycaprolactone/Polylactic Acid Nanofibers

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dc.contributor.authorEKENTOK ATICI, CEYDA
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorÇAM, MUHAMMET EMİN
dc.contributor.authorTATAR, ESRA
dc.contributor.authorYAVUZ, AYŞE NUR
dc.contributor.authorsAydin S., Kabaoglu I., Guler E., Topal F., YAVUZ A. N., EKENTOK ATICI C., TATAR E., Gurbuz F., GÜNDÜZ O., ÇAM M. E.
dc.date.accessioned2023-03-20T08:23:00Z
dc.date.available2023-03-20T08:23:00Z
dc.date.issued2022-05-01
dc.description.abstractNanofibers (NFs) offer an alternative option for the treatment of Alzheimer\"s disease (AD) by addressing unmet clinical problems. In this study, anti-AD drugs, donepezil (DO) and curcumin (CUR), are loaded in polylactic acid/polycaprolactone NFs. The effect of fiber diameter on drug release behavior is mainly observed, and the successful loading of DO and CUR to NFs is demonstrated. The tensile strength of DO/CUR-loaded NFs (DNFs) with lower fiber diameter is found to be higher. The working temperature is increased by the decrease of glass transition temperature and increase of the melting temperature after loading drugs. Furthermore, the increase in the percentage of swelling and decrease in the degradation rate for NFs are observed due to the increase of fiber diameter. Encapsulation efficiency and burst release percentages for DNFs are augmented by the increase of fiber diameter. Nevertheless, DNFs exhibit a sustained drug release manner over 2 weeks. NFs do not demonstrate a toxic effect on L929 (mouse fibroblast) cells, and additionally, they promote cell proliferation. Considering all these results, it is proven that the fiber diameter affects all characteristic features of NFs, and DNFs lead to a new and promising drug delivery system for the treatment of AD.
dc.identifier.citationAydin S., Kabaoglu I., Guler E., Topal F., YAVUZ A. N., EKENTOK ATICI C., TATAR E., Gurbuz F., GÜNDÜZ O., ÇAM M. E., "A Comparison Study of Fiber Diameter's Effect on Characteristic Features of Donepezil/Curcumin-Loaded Polycaprolactone/Polylactic Acid Nanofibers", MACROMOLECULAR MATERIALS AND ENGINEERING, cilt.307, sa.5, 2022
dc.identifier.doi10.1002/mame.202100855
dc.identifier.issn1438-7492
dc.identifier.issue5
dc.identifier.urihttps://hdl.handle.net/11424/287655
dc.identifier.volume307
dc.language.isoeng
dc.relation.ispartofMACROMOLECULAR MATERIALS AND ENGINEERING
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKimya
dc.subjectFizikokimya
dc.subjectPolimer Karakterizasyonu
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectChemistry
dc.subjectPhysical Chemistry
dc.subjectCharacterization of Polymers
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMALZEME BİLİMİ, ÇOKDİSİPLİNLİ
dc.subjectMalzeme Bilimi
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectPOLİMER BİLİMİ
dc.subjectTemel Bilimler (SCI)
dc.subjectMATERIALS SCIENCE, MULTIDISCIPLINARY
dc.subjectMATERIALS SCIENCE
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectPOLYMER SCIENCE
dc.subjectCHEMISTRY
dc.subjectNatural Sciences (SCI)
dc.subjectMetals and Alloys
dc.subjectMaterials Chemistry
dc.subjectPolymers and Plastics
dc.subjectChemistry (miscellaneous)
dc.subjectGeneral Materials Science
dc.subjectGeneral Chemistry
dc.subjectPhysical Sciences
dc.subjectAlzheimer's disease
dc.subjectcurcumin
dc.subjectdonepezil hydrochloride
dc.subjectelectrospinning
dc.subjectnanofibers
dc.subjectIN-VITRO
dc.subjectELECTROSPUN NANOFIBERS
dc.subjectALZHEIMERS-DISEASE
dc.subjectSUSTAINED-RELEASE
dc.subjectDRUG-RELEASE
dc.subjectDELIVERY
dc.subjectCURCUMIN
dc.subjectMICROSPHERES
dc.subjectTETRACYCLINE
dc.subjectDEGRADATION
dc.titleA Comparison Study of Fiber Diameter's Effect on Characteristic Features of Donepezil/Curcumin-Loaded Polycaprolactone/Polylactic Acid Nanofibers
dc.typearticle
dspace.entity.typePublication
local.avesis.id4f18df9c-9321-4aac-8270-5d421239157b
local.indexed.atWOS
local.indexed.atSCOPUS
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