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Hypothalamic obesity in children: pathophysiology to clinical management

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dc.contributor.authorBEREKET, ABDULLAH
dc.contributor.authorsHaliloglu, Belma; Bereket, Abdullah
dc.date.accessioned2022-03-10T15:25:17Z
dc.date.available2022-03-10T15:25:17Z
dc.date.issued2015
dc.description.abstractHypothalamic obesity (HyOb) is a complex neuroendocrine disorder caused by damage to the hypothalamus, which results in disruption of energy regulation. The key hypothalamic areas of energy regulation are the ARC (arcuate nucleus), the VMH (ventromedial hypothalamus), the PVN (paraventriculer nuclei) and the LHA (lateral hypothalamic area). These pathways can be disrupted mechanically by hypothalamic tumors, neurosurgery, inflammatory disorders, radiotherapy and trauma or functionally as such seen in genetic diseases. Rapid weight gain and severe obesity are the most striking features of HyOb and caused by hyperphagia, reduced basal metabolic rate (BMR) and decreased physical activity. HyOb is usually unresponsive to diet and exercise. Although, GLP-1 and its anologs seem to be a new agent, there is still no curative treatment. Thus, prevention is of prime importance and the clinicians should be alert and vigilant in patients at risk for development of HyOb.
dc.identifier.doi10.1515/jpem-2014-0512
dc.identifier.eissn2191-0251
dc.identifier.issn0334-018X
dc.identifier.pubmed25781673
dc.identifier.urihttps://hdl.handle.net/11424/220190
dc.identifier.wosWOS:000353793000004
dc.language.isoeng
dc.publisherWALTER DE GRUYTER GMBH
dc.relation.ispartofJOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectchildren
dc.subjectcraniopharygioma
dc.subjecthypothalamus
dc.subjectobesity
dc.subjectPRADER-WILLI-SYNDROME
dc.subjectINCREASED DAYTIME SLEEPINESS
dc.subjectGASTRIC BYPASS-SURGERY
dc.subjectEARLY-ONSET OBESITY
dc.subjectBODY-MASS INDEX
dc.subjectCHILDHOOD CRANIOPHARYNGIOMA
dc.subjectFOOD-INTAKE
dc.subjectLEPTIN RECEPTOR
dc.subjectADIPOSE-TISSUE
dc.subjectRISK-FACTORS
dc.titleHypothalamic obesity in children: pathophysiology to clinical management
dc.typereview
dspace.entity.typePublication
local.avesis.id4fc9f23d-7589-49e0-a55a-401b8867262a
local.import.packageSS5
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages11
oaire.citation.endPage513
oaire.citation.issue5-6
oaire.citation.startPage503
oaire.citation.titleJOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
oaire.citation.volume28
relation.isAuthorOfPublication669e9474-4e39-453f-a4bc-4ede9cb5abac
relation.isAuthorOfPublication.latestForDiscovery669e9474-4e39-453f-a4bc-4ede9cb5abac

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