Publication:
In vitro effects of clarithromycin on human polymorphonuclear leukocyte functions

dc.contributor.authorKADİR, TANJU
dc.contributor.authorsKadir, T; Izzetin, FV; Cevikbas, A; Johansson, CB; Clark, P
dc.date.accessioned2022-03-12T16:58:13Z
dc.date.available2022-03-12T16:58:13Z
dc.date.issued2000
dc.description.abstractBackground: It has been shown that antibacterial agents affect polymorphonuclear leukocytes (PMNs), which are active in the body's first line of defense, in different ways. However, few studies have investigated the effects of tablet dosage forms as opposed to pure powder forms. There is a need to demonstrate the clinical relevance of previous results with commercially available products. Methods: We examined the effects of clarithromycin solutions, prepared separately from either pure powder or commercially available tablets (250 mg), on human PMNs. The in vitro effects of each solution, adjusted to therapeutic concentration (1 mg/l), on PMN adherence, chemotaxis, phagocytosis, candidacidal capacity and superoxide production were studied. Results: Solutions prepared from pure clarithromycin powder did not affect the adherence, phagocytosis or superoxide production of PMNs, but did inhibit (p < 0.05) chemotaxis and candidacidal capacity. By contrast, a decrease (p < 0.05) in all functions except phagocytosis was observed with solutions prepared from the tablet dosage form of clarithromycin. Conclusion: The results of this study suggest that the tablet dosage form of clarithromycin may have a more pronounced inhibitory effect on human PMN functions than solutions prepared from the pure powder form. Copyright (C) 2000 S. Karger AG, Basel.
dc.identifier.doi10.1159/000007279
dc.identifier.issn0009-3157
dc.identifier.pubmed10765036
dc.identifier.urihttps://hdl.handle.net/11424/227020
dc.identifier.wosWOS:000086707900009
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofCHEMOTHERAPY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectclarithromycin
dc.subjectadherence
dc.subjectchemotaxis
dc.subjectphagocytosis-candidacidal capacity
dc.subjectsuperoxide anion generation
dc.subjectNEUTROPHIL FUNCTION
dc.subjectOXIDATIVE BURST
dc.subjectANTIBIOTICS
dc.subjectINVITRO
dc.subjectINHIBITION
dc.subjectCHEMOTAXIS
dc.subjectMACROLIDES
dc.titleIn vitro effects of clarithromycin on human polymorphonuclear leukocyte functions
dc.typearticle
dspace.entity.typePublication
local.avesis.id9fcd8a0a-cedc-4e85-8394-270301e9d9d2
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages6
oaire.citation.endPage203
oaire.citation.issue3
oaire.citation.startPage198
oaire.citation.titleCHEMOTHERAPY
oaire.citation.volume46
relation.isAuthorOfPublicatione0ebf174-b3eb-48f5-9478-ae7c8a0747d8
relation.isAuthorOfPublication.latestForDiscoverye0ebf174-b3eb-48f5-9478-ae7c8a0747d8

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