Publication:
Effects of montelukast sodium on tendon healing: An experimental study

Simple item page
dc.contributor.authorAKAKIN, DİLEK
dc.contributor.authorsPolat, Atilla; Canbora, Mehmet Kerem; Akakin, Dilek; Aykanat, Faruk
dc.date.accessioned2022-03-14T10:55:41Z
dc.date.available2022-03-14T10:55:41Z
dc.date.issued2013
dc.description.abstractIntroduction: Montelukast sodium (MS) a selective leukotriene antagonist of the cysteinyl leukotriene receptor, has been used in the treatment of asthma and allergic rhinitis. In this study, we evaluated the effect of MS on the early inflammatory phase (histological) of nonsynovial tendon healing. Materials and Methods: Rats were divided randomly into two groups (n = 6 each). MS (Singulair) was administered to one group at 10 mg/kg/day [250 g/day intraperitoneally (i.p.)]. The control group was administered 250 g/day of 0.9% saline i.p. This nonsynovial tendon was longitudinally divided at the midportion, cut transversely and then sutured. In both groups, the rats were sacrificed by decapitation 10 days later. Results: Decreased inflammatory cell infiltration and more properly oriented collagen fibres were observed in the MS group's histopathological specimens as compared to the control group's (P < 0.05). Additionally, vascularity was decreased in the MS group. Conclusion: MS decreased tendon healing, apparently by inhibiting the early inflammatory phase of nonsynovial tendon healing.
dc.identifier.doi10.4103/0019-5413.118207
dc.identifier.eissn1998-3727
dc.identifier.issn0019-5413
dc.identifier.pubmed24133311
dc.identifier.urihttps://hdl.handle.net/11424/245487
dc.identifier.wosWOS:000325400200012
dc.language.isoeng
dc.publisherSPRINGER HEIDELBERG
dc.relation.ispartofINDIAN JOURNAL OF ORTHOPAEDICS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAchilles tendon
dc.subjectmontelukast
dc.subjectrats
dc.subjecttendon
dc.subjectRECEPTOR ANTAGONIST
dc.titleEffects of montelukast sodium on tendon healing: An experimental study
dc.typearticle
dspace.entity.typePublication
local.avesis.ide6c7608b-20d8-49b6-bfec-37a226e0cbc8
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages5
oaire.citation.endPage504
oaire.citation.issue5
oaire.citation.startPage500
oaire.citation.titleINDIAN JOURNAL OF ORTHOPAEDICS
oaire.citation.volume47
relation.isAuthorOfPublicationc97c0ebf-ffce-4b27-a933-941a53767b0d
relation.isAuthorOfPublication.latestForDiscoveryc97c0ebf-ffce-4b27-a933-941a53767b0d

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
polat2013.pdf.pdf
Size:
1.52 MB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs