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The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19

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dc.contributor.authorKARAHASAN, AYŞEGÜL
dc.contributor.authorsYazan, Ceyda Dincer; Ilgin, Can; Elbasan, Onur; Apaydin, Tugce; Dashdamirova, Saida; Yigit, Tayfun; Sili, Uluhan; Yagci, Aysegul Karahasan; Sirikci, Onder; Haklar, Goncagul; Gozu, Hulya
dc.date.accessioned2022-03-14T09:34:13Z
dc.date.available2022-03-14T09:34:13Z
dc.date.issued2021-08-13
dc.description.abstractBackground. COVID-19 infection may have multiorgan effects in addition to effects on the lungs and immune system. Recently, studies have found thyroid function abnormalities in COVID-19 cases which were interpreted as euthyroid sick syndrome (ESS) or destructive thyroiditis. Therefore, in this study, we aimed to evaluate the thyroid function status and thyroid autoimmunity in COVID-19 patients. Material and Method. 205 patients were included. The medical history and laboratory parameters at admission were collected from medical records. Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroid peroxidase antibody, and thyroglobulin antibody were measured, and patients were classified according to thyroid function status. Results. 34.1% of the patients were euthyroid. Length of hospitalization (p<0.001), rate of oxygen demand (p<0.001), and intensive care unit (ICU) admission (p=0.022) were lower, and none of the euthyroid patients died. 108 (52.6%) patients were classified to have ESS, 57 were classified as mild, and 51 were moderate. The inflammatory parameters were higher in patients with moderate ESS. In cluster analysis, a high-risk group with a lower median FT3 value (median = 2.34 ng/L; IQR = 0.86), a higher median FT4 value (median = 1.04 ng/dL; IQR = 0.33), and a lower median TSH value (median = 0.62 mIU/L; IQR = 0.59) included 8 of 9 died patients and 25 of the 31 patients that were admitted to ICU. Discussion. Length of hospitalization, oxygen demand, ICU admission, and mortality were lower in euthyroid patients. Moreover, none of the euthyroid patients died. In conclusion, evaluation of thyroid function tests during COVID-19 infection may give information about the prognosis of disease.
dc.identifier.doi10.1155/2021/2395212
dc.identifier.eissn1687-8345
dc.identifier.issn1687-8337
dc.identifier.pubmed34422043
dc.identifier.urihttps://hdl.handle.net/11424/243276
dc.identifier.wosWOS:000691080200001
dc.language.isoeng
dc.publisherHINDAWI LTD
dc.relation.ispartofINTERNATIONAL JOURNAL OF ENDOCRINOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGUIDELINES
dc.subjectMANAGEMENT
dc.subjectDISEASE
dc.titleThe Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19
dc.typearticle
dspace.entity.typePublication
local.avesis.id28370995-4014-492b-a8b0-4c2d77002933
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber2395212
local.journal.numberofpages11
oaire.citation.titleINTERNATIONAL JOURNAL OF ENDOCRINOLOGY
oaire.citation.volume2021
relation.isAuthorOfPublicationd8b6c313-4dc1-4253-adf4-6e2e6d68af90
relation.isAuthorOfPublication.latestForDiscoveryd8b6c313-4dc1-4253-adf4-6e2e6d68af90

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