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HPLC-MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentata

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dc.contributor.authorDOĞAN, AHMET
dc.contributor.authorsZengin, Gokhan; Diuzheva, Alina; Jeko, Jozsef; Cziaky, Zoltan; Bulut, Gizem; Dogan, Ahmet; Haznedaroglu, Mehmet Zeki; Rengasamy, Kannan R. R.; Lobine, Devina; Bahadori, Mir Babak; Mahomoodally, Mohamad Fawzi
dc.date.accessioned2022-03-12T22:27:46Z
dc.date.available2022-03-12T22:27:46Z
dc.date.issued2018
dc.description.abstractArnelanchierparviflora var. dentata is an endemic medicinal plant traditionally consumed to treat stomach pain, cardiovascular diseases, and urinary tract infections in Turkey's folk medicine. Although Amelanchier genus is an excellent source of phytochemicals with a panoply of biological activities, no report has been made available on Amelanchier parviflora var. dentata. Thus, the metabolic profiles of methanol, ethyl acetate, and water extracts were obtained using HPLC-MS/MS. Besides, the pharmacological properties such as antioxidant activity and enzyme inhibition effects against acetyl/butyrylcholinesterase, tyrosinase, alpha-amylase, and alpha-glucosidase were evaluated. In total, 62, 38, and 16 metabolites were Identified from the methanolic, water, and ethyl acetate extracts, respectively. The identified metabolites belong to anthocyanins, phenolic acids, and flavonoids. The tested extracts exhibited different enzyme inhibitory activity against cholinesterases (acetylcholinesterase: 0.52-2.47 mg GEs/g extract and butyrylcholinesterase: 0.47-3.59 mg GEs/g extract), tyrosinase (19,0-145.54 mg KAEs/g extract), alpha-amylase (0.23-1.10 mmol ACEs/g extract), and alpha-glucosidase (8.89-9.92 mmol ACEs/ g extract). Evidence from the present study supports the necessity for more research in an endeavor to discover biologically active secondary metabolites from A. parviflora to manage specific ailments.
dc.identifier.doi10.1016/j.indcrop.2018.08.042
dc.identifier.eissn1872-633X
dc.identifier.issn0926-6690
dc.identifier.urihttps://hdl.handle.net/11424/235241
dc.identifier.wosWOS:000447569100081
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAmelanchier parviflora
dc.subjectAntioxidants
dc.subjectChemical fingerprints
dc.subjectEnzyme inhibitors
dc.subjectPhenolics
dc.subjectAnthocyanins
dc.subjectANTIOXIDANT ACTIVITY
dc.subjectALPHA-GLUCOSIDASE
dc.subjectALNIFOLIA NUTT.
dc.subjectPHENOLIC-COMPOUNDS
dc.subjectPLANTS
dc.subjectBERRIES
dc.subjectTURKEY
dc.subjectACID
dc.subjectACETYLCHOLINESTERASE
dc.subjectANTICHOLINESTERASE
dc.titleHPLC-MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentata
dc.typearticle
dspace.entity.typePublication
local.avesis.ide3896bab-88b2-44f1-bf4a-c31c1658b8c0
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages8
local.journal.quartileQ1
oaire.citation.endPage706
oaire.citation.startPage699
oaire.citation.titleINDUSTRIAL CROPS AND PRODUCTS
oaire.citation.volume124
relation.isAuthorOfPublication34e928c8-270a-41b3-8311-23fba8b897ed
relation.isAuthorOfPublication.latestForDiscovery34e928c8-270a-41b3-8311-23fba8b897ed

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