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The Effect of Algan Hemostatic Agent (AHA) on Wound Healing

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorsAksoy, Halil; Sener, Azize; Akakin, Dilek; Sen, Ali; Ozakpinar, Ozlem Bingol; Ozcan, Sinemcan; Simsek, Ahmet Kaan; Sekerler, Turgut; Guzel, Sevket Ergun; Midi, Ahmet
dc.date.accessioned2022-03-14T09:23:19Z
dc.date.available2022-03-14T09:23:19Z
dc.date.issued2020-09-04
dc.description.abstractObjective: The Algan Hemostatic Agent (AHA) is a novel herbal originated blood stopper. The aim of this study is to investigate the effect of AHA on wound healing on excisional wound model in rats. Methods: In this study, 54 adult Wistar albino rats were used. Rats were divided into 3 groups (saline, Madecassol (R) and AHA). Each group was then divided into 3 subgroups as the 3rd, 7th and 14th days. Two wounds were created in the dorsal thoracic region of the rats. One of the lesions was used for histopathological examinations and the other for hydroxyproline measurement. In order to evaluate the wound healing, wound area were measured during the whole treatment period and animals were sacrificed at the end of the 3rd, 7th and 14th days and tissue samples were taken for the determination of hydroxyproline levels. Results: AHA treatment did not cause significant difference in hydroxyproline level on days 3, 7, 14. The contraction percentage of wound area was higher in the AHA group on day 7 than that of the control group. However, the difference was not statistically significant (p>0.05). On days 3 and 14, no significant difference was detected in the contraction percentage of wound area between the control and the AHA groups. AHA and Madecassol (R) results of epidermis regeneration on the 14th day, neutrophil infiltration on the 7th day and edema on the 3rd, 7th and 14th days were different in terms of histopathological parameters compared to the control group. Conclusion: Despite good histological findings, AHA did not significantly accelerate wound healing, but did not adversely affect wound healing as well.
dc.identifier.doi10.33808/marusbed.767312
dc.identifier.issn2459-1459
dc.identifier.urihttps://hdl.handle.net/11424/243054
dc.identifier.wosWOS:000583482500016
dc.language.isoeng
dc.publisherMARMARA UNIV, INST HEALTH SCIENCES
dc.relation.ispartofCLINICAL AND EXPERIMENTAL HEALTH SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlgan hemostatic agent
dc.subjectMadecassol (R)
dc.subjectwound healing
dc.subjecthydroxyproline
dc.subjectANKAFERD BLOOD STOPPER
dc.subjectETHANOL EXTRACT
dc.titleThe Effect of Algan Hemostatic Agent (AHA) on Wound Healing
dc.typearticle
dspace.entity.typePublication
local.avesis.id1177069c-cc07-4cdc-ba92-a7696872fab6
local.import.packageSS16
local.indexed.atWOS
local.indexed.atTRDIZIN
local.journal.numberofpages6
oaire.citation.endPage284
oaire.citation.issue3
oaire.citation.startPage279
oaire.citation.titleCLINICAL AND EXPERIMENTAL HEALTH SCIENCES
oaire.citation.volume10
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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