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Frequency of BK virus nephropathy in graft dysfunction biopsies

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dc.contributor.authorTUĞLULAR, ZÜBEYDE SERHAN
dc.contributor.authorsCakalagaoglu, Fulya; Erbarut, Ipek; Tuglular, Serhan
dc.date.accessioned2022-03-14T08:23:03Z
dc.date.available2022-03-14T08:23:03Z
dc.date.issued2007-02-22
dc.description.abstractBackground. BK virus nephropathy is the most common type of viral disease to occur following renal transplantation. Although its frequency differs according to transplantation center, the rate is between 1.5% and 20%. Diagnosis can be established histologically by renal allograft biopsy. The aim of this study was to determine the frequency of BK virus nephropathy in patients who had had a renal biopsy for graft dysfunction at our center. Methods. Biopsies received in the last 3 years from patients with graft dysfunction were used in the study. We have found the BK virus in biopsies of 5 of 41 patients (11%). All these patients had been treated with immunosuppressive drugs following transplantation surgery. Biopsies were performed because of disturbance of renal function. Only 1 patient had had a urinary examination. Morphological diagnosis of BK virus nephropathy was followed by serological examination. Results. The most frequent morphological changes with BK virus infection in our samples were basophilia, nuclear inclusions, and nuclear enlargement on tubular epithelium. Decoy cells were not found in the biopsy from the only patient who had had a urinary examination. Treatment of the patients with BK virus nephropathy with immunosuppressive drugs has been reduced, and antiviral treatment has been started. Conclusion. BK virus nephropathy should be kept in mind in the differential diagnosis of transplant rejection and drug toxicity.
dc.identifier.doi10.1002/dat.20101
dc.identifier.issn0090-2934
dc.identifier.urihttps://hdl.handle.net/11424/241670
dc.identifier.wosWOS:000244541700008
dc.language.isoeng
dc.publisherJOHN WILEY & SONS INC
dc.relation.ispartofDIALYSIS & TRANSPLANTATION
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRENAL-TRANSPLANT RECIPIENTS
dc.subjectHUMAN POLYOMA-VIRUS
dc.subjectINTERSTITIAL NEPHRITIS
dc.subjectINFECTION
dc.subjectDIAGNOSIS
dc.subjectDISEASE
dc.titleFrequency of BK virus nephropathy in graft dysfunction biopsies
dc.typearticle
dspace.entity.typePublication
local.avesis.id5e4918b1-d966-4e33-aecb-9544751fc12f
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages3
oaire.citation.endPage+
oaire.citation.issue3
oaire.citation.startPage122
oaire.citation.titleDIALYSIS & TRANSPLANTATION
oaire.citation.volume36
relation.isAuthorOfPublication3ea0c6f9-3408-46b6-b382-144ccbf7bc72
relation.isAuthorOfPublication.latestForDiscovery3ea0c6f9-3408-46b6-b382-144ccbf7bc72

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