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Antibiotic resistance

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dc.contributor.authorRAYAMAN, PERVİN
dc.contributor.authorsRAYAMAN P.
dc.date.accessioned2023-07-17T09:00:26Z
dc.date.available2023-07-17T09:00:26Z
dc.date.issued2023-01-01
dc.description.abstractAntibiotics are medicines used to prevent and treat bacterial infections. Antibiotic resistance occurs when the response of bacteria to medicines. Unfortunately nowadays the emergence of resistance among bacterial pathogens is a major public worldwide health problem. Antibiotic resistance is a vital problem since it concerns human, animals, plants and environmental factors. Additionally, multidrug-resistant organisms have emerged not only in the hospital but also in the community. The presence of antibiotic-resistant bacteria reservoirs outside the hospital is a worlwide issue which concerns many scientist. Moreover, according to the World Health Organization (WHO) antibiotic resistance is one of the 3 most important public health threats of the 21st century. Furthermore, according to Centers for Disease Control and Prevention (CDC) antibiotic resistance is estimated to cause around 300 million premature deaths by 2050, with a loss of up to $100 trillion (£64 trillion) to the global economy. As it is known the mechanisms of antimicrobial resistance are modifications of the antimicrobial target, Enzymatic degradation of antibacterial drugs, changes in membrane permeability to antibiotics, changes in important metabolic pathways, activation of efflux mechanism. During the modifications of the antimicrobial target in order to avoid the action of the antibiotic bacteria have evolved different tactics one of which is target protection (avoiding the antibiotic to reach its binding site) and the other one is modifications of the target site which results in decreased affinity for the antibiotic molecule. For example drugs affected by this mechanism include tetracycline (Tet[M] and Tet[O]), fluoroquinolones (Qnr) and fusidic acid (FusB and FusC) during target protections. The methicillin resistance seen in Staphylococcus aureus due to replacement of an exogenous PBP (PBP2a) and vancomycin resistance in enterococci is an example of replacement or bypass of the original target. The β-Lactamases, macrolide esterases and aminoglycoside acetyltransferases are take place in enzymatic degradation of antibacterial drugs. Many of the antibiotics used in clinical practice have intracellular bacterial targets. Therefore, the compound must penetrate the outer and/or cytoplasmic membrane in order to exert its antimicrobial effect. β-lactams, tetracyclines and some fluoroquinolones are particularly affected by changes in permeability of the outer membrane. Also one of the most important mechanisms of antimicrobial resistance is the activation of efflux mechanisms. Many classes of efflux pumps have been characterized in both gram-negative and gram-positive pathogens. It is known that more than 20 different tet genes cause tetracycline resistance. Additionally, MDR efflux pumps like AcrAB-TolC in Enterobacteriaceae and MexAB-OprM in P. aeruginosa are able to extrude tetracyclines (including tigecycline) as part of their contribution to multidrug resistance. In order to combat with antibiotic resistance one should protect him or herself and also his or her family. As it is known infections caused by multi-drug antibiotic-resistant germs are quiet difficult, and sometimes impossible to treat. However we can help stop the spread of these microorganisms. Normally, antibiotic resistance happens when microorganisms like bacteria and fungi develop the ability to defeat the drugs designed to kill them. People can not completely avoid getting an infection, but there are few precautions that you can take in order to reduce infection risk. These are, washing hands, getting vaccinated, using antibiotics appropriately, preparing food safely, being vigilant when traveling abroad and preventing sexually transmitted diseases.Consequently, antibiotic resistance is a worlwide problem which concerns many scientist since combating with it getting hard day by day. Merely, if the neccessary precaution metioned about are taken, antibiotic resistance could be minimalized.
dc.identifier.citationRAYAMAN P., "ANTIBIOTIC RESISTANCE", Journal of Research in Pharmacy, cilt.27, ss.4-6, 2023
dc.identifier.doi10.29228/jrp.385
dc.identifier.endpage6
dc.identifier.issn2630-6344
dc.identifier.startpage4
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/b83fb5b8-e8c0-4c3e-94ff-0e6bf97be733/file
dc.identifier.urihttps://hdl.handle.net/11424/291319
dc.identifier.volume27
dc.language.isoeng
dc.relation.ispartofJournal of Research in Pharmacy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTemel Eczacılık Bilimleri
dc.subjectEczacılık
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectBasic Pharmaceutics Sciences
dc.subjectPharmacology and Therapeutics
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectLife Sciences (LIFE)
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji (tıbbi)
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology (medical)
dc.subjectAntibiotic resistance
dc.subjectefflux mechanisms
dc.subjectmultidrug-resistant organisms
dc.titleAntibiotic resistance
dc.typearticle
dspace.entity.typePublication
local.avesis.idb83fb5b8-e8c0-4c3e-94ff-0e6bf97be733
local.indexed.atSCOPUS
relation.isAuthorOfPublication858e58c3-932e-40e3-8667-761dcec58420
relation.isAuthorOfPublication.latestForDiscovery858e58c3-932e-40e3-8667-761dcec58420

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