Publication:
The effects of alpha-lipoic acid (ALA) on the urinary bladder injury in rats exposed to chronic stress: a histochemical study

Simple item page
dc.contributor.authorŞİRVANCI, SERAP
dc.contributor.authorsYurdakul N., Cikler E., Toklu H. Z. , ŞİRVANCI S.
dc.date.accessioned2022-12-02T12:59:37Z
dc.date.available2022-12-02T12:59:37Z
dc.date.issued2022-01-01
dc.description.abstractObjective: In the present study, we aimed to investigate the morphological and biochemical effects of alpha-lipoic acid (ALA) on bladder injury caused by water avoidance stress (WAS) and to show its effect on the number of degranulated mast cells, which increase after stress.Materials and Methods: Wistar albino rats were subjected to WAS and the animals in the treatment group were injected ALA. After the urinary bladder tissues were subjected to routine tissue processing, hematoxylin-eosin staining and periodic acid-Schiff reaction were applied to observe general morphology and acidic toluidine blue method to investigate mast cells. Biochemical assessments of malondialdehyde (MDA) and glutathione (GSH) were also obtained. Transmission electron microscope was used for the ultrastructural, and scanning electron microscope for the topographical analyses. Results: The experiments showed that chronic stress caused injury in the bladder, increased degranulated and total number of mast cells and decreased GSH and increased MDA levels. ALA treatment after WAS ameliorated bladder injury in most areas, decreased degranulated and total mast cell number and increased GSH and decreased MDA levels.Conclusion: It was concluded that ALA can be a useful agent in the treatment of interstitial cystitis.
dc.identifier.citationYurdakul N., Cikler E., Toklu H. Z. , ŞİRVANCI S., "The effects of alpha-lipoic acid (ALA) on the urinary bladder injury in rats exposed to chronic stress: A histochemical study", MARMARA MEDICAL JOURNAL, cilt.35, sa.3, ss.263-269, 2022
dc.identifier.doi10.5472/marumj.1191211
dc.identifier.endpage269
dc.identifier.issn1309-9469
dc.identifier.issue3
dc.identifier.startpage263
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/eb2fce4e-c28c-417b-ba1c-a046b72dfc91/file
dc.identifier.urihttps://hdl.handle.net/11424/283507
dc.identifier.volume35
dc.language.isoeng
dc.relation.ispartofMARMARA MEDICAL JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectGenel Sağlık Meslekleri
dc.subjectPatofizyoloji
dc.subjectTemel Bilgi ve Beceriler
dc.subjectDeğerlendirme ve Teşhis
dc.subjectDahiliye
dc.subjectAile Sağlığı
dc.subjectTıp (çeşitli)
dc.subjectGenel Tıp
dc.subjectGeneral Health Professions
dc.subjectPathophysiology
dc.subjectFundamentals and Skills
dc.subjectAssessment and Diagnosis
dc.subjectInternal Medicine
dc.subjectFamily Practice
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Medicine
dc.subjectAlpha-lipoic acid (ALA)
dc.subjectInterstitial cystitis
dc.subjectMast cell
dc.subjectStress
dc.subjectUrinary bladder
dc.subjectMAST-CELL DEGRANULATION
dc.subjectINTERSTITIAL CYSTITIS
dc.subjectANTIOXIDANT
dc.subjectRECEPTOR
dc.subjectPERMEABILITY
dc.subjectINFLAMMATION
dc.subjectFRACTALKINE
dc.subjectEXPRESSION
dc.subjectMELATONIN
dc.subjectAlpha-lipoic acid (ALA)
dc.subjectInterstitial cystitis
dc.subjectMast cell
dc.subjectStress
dc.subjectUrinary bladder
dc.titleThe effects of alpha-lipoic acid (ALA) on the urinary bladder injury in rats exposed to chronic stress: a histochemical study
dc.typearticle
dspace.entity.typePublication
local.avesis.ideb2fce4e-c28c-417b-ba1c-a046b72dfc91
local.indexed.atWOS
local.indexed.atSCOPUS
relation.isAuthorOfPublicationfcdb4c83-6090-4b1e-8758-448d3b32b73a
relation.isAuthorOfPublication.latestForDiscoveryfcdb4c83-6090-4b1e-8758-448d3b32b73a

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
30.pdf
Size:
1.5 MB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs