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The effect of propofol and alfentanil on the increase in intraocular pressure due to succinylcholine and intubation

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dc.contributor.authorUMUROĞLU, TÜMAY
dc.contributor.authorsEti, Z; Yayci, A; Umuroglu, T; Gogus, FY; Bozkurt, N
dc.date.accessioned2022-03-12T16:59:38Z
dc.date.available2022-03-12T16:59:38Z
dc.date.issued2000
dc.description.abstractPURPOSE. The aim of this study was to evaluate the effects of propofol and alfentanil on the increase in intraocular pressure (IOP) due to succinylcholine and intubation, in comparison with thiopental sodium and vecuronium bromide. METHODS. Forty patients aged 20-50 years, scheduled for elective surgery requiring endotracheal intubation, were assigned to four groups of ten. General anesthesia was induced with 2.5 mg/kg propofol in Group 1, 2.5 mg/kg propofol and 10 mu g/kg alfentanil in Group II and 5 mg/kg thiopental in Groups III and IV muscle relaxation was obtained with either 1.5 mg/kg succinylcholine (Group I, II and III) or 0.1 mg/kg vecuronium bromide (Group IV). In all patients mean arterial pressure, heart rate, oxygen saturation and IOP were recorded before (baseline) and after induction, after the muscle relaxant and after endotracheal intubation. RESULTS. Compared with their baseline values in Group I IOP decreased significantly after propofol (p<0.01) and increased significantly after intubation (p<0.01). In Group II IOP decreased significantly after propofol and alfentanyl (p<0.001), remained low after succinylcholine (p<0.01) and did not change after intubation. In Group III IOP decreased significantly after thiopental (p<0.001) and increased significantly after intubation (p<0.001). In Group IV ii decreased significantly after thiopental (p<0.001), remained low after vecuronium (p<0.001) and increased significantly after intubation (p<0.05). CONCLUSIONS. In all Groups, IOP did not increase significantly after succinylcholine, but only anesthesia induced with propofol and alfentanil prevented the increase in IOP due to intubation.
dc.identifier.doi10.1177/112067210001000202
dc.identifier.issn1120-6721
dc.identifier.pubmed10887919
dc.identifier.urihttps://hdl.handle.net/11424/227219
dc.identifier.wosWOS:000088103200002
dc.language.isoeng
dc.publisherWICHTIG EDITORE
dc.relation.ispartofEUROPEAN JOURNAL OF OPHTHALMOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectintraocular pressure
dc.subjectpropofol
dc.subjectalfentanil
dc.subjectsuccinylcholine
dc.subjectintubation
dc.subjectTRACHEAL INTUBATION
dc.subjectSUXAMETHONIUM
dc.subjectANESTHESIA
dc.subjectVECURONIUM
dc.titleThe effect of propofol and alfentanil on the increase in intraocular pressure due to succinylcholine and intubation
dc.typearticle
dspace.entity.typePublication
local.avesis.id82351a98-797b-47a6-9ea3-096eb75b4e27
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage109
oaire.citation.issue2
oaire.citation.startPage105
oaire.citation.titleEUROPEAN JOURNAL OF OPHTHALMOLOGY
oaire.citation.volume10
relation.isAuthorOfPublication6c6d2ae6-d39d-452b-a723-36ede3fcb06b
relation.isAuthorOfPublication.latestForDiscovery6c6d2ae6-d39d-452b-a723-36ede3fcb06b

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