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Production and characterization of PLA/HA/GO nanocomposite scaffold

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dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorsOktay B., Ahlatcıoğlu Özerol E., Şahin A., Gunduz O., Ustundag C. B.
dc.date.accessioned2023-08-10T07:51:04Z
dc.date.available2023-08-10T07:51:04Z
dc.date.issued2022-08-12
dc.description.abstract© 2022 Wiley-VCH GmbH.Polylactic acid (PLA) composite nanofibers combined with hydroxyapatite (HA) and graphene oxide (GO) nanoparticles were produced by electrospinning to create excellent biodegradable and durable scaffolds to be used in tissue engineering. The properties of the pure PLA, PLA/HA, PLA/GO, and PLA/HA/GO nanocomposite scaffolds were analyzed in chemical, morphological, mechanical, and biocompatibility. Morphology and composition were investigated by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), respectively. To predict the cytocompatibility of these scaffolds, HFF-1 cells were cultured and the respective cell adhesion and proliferation were investigated by fluorescence microscopy, SEM, and MTT assay. FTIR results showed the successful synthesis of HA and GO nanoparticles. SEM images showed that the PLA/HA/GO scaffold is ideal for cell attachment and proliferation in tissue regeneration. Mechanical test results showed that the tensile strength and elastic modulus of PLA nanofibers could be increased by adding 0,8 wt % HA and 0,4 wt % GO. The PLA/HA/GO scaffold exhibited the highest tensile strength of other scaffolds. MTT assay revealed that the PLA/HA/GO scaffold showed significantly high biocompatibility with 105 % cell viability. Therefore, PLA/HA/GO scaffold with 0,8 wt %HA and 0,4 wt %GO possessing high tensile strength as well as good cell proliferation is an excellent and versatile biomaterial for tissue engineering applications.
dc.identifier.citationOktay B., Ahlatcıoğlu Özerol E., Şahin A., Gunduz O., Ustundag C. B., "Production and Characterization of PLA/HA/GO Nanocomposite Scaffold", ChemistrySelect, cilt.7, sa.30, 2022
dc.identifier.doi10.1002/slct.202200697
dc.identifier.issn2365-6549
dc.identifier.issue30
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85136184751&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/292275
dc.identifier.volume7
dc.language.isoeng
dc.relation.ispartofChemistrySelect
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKimya
dc.subjectBiyokimya
dc.subjectAlkoloidler
dc.subjectTemel Bilimler
dc.subjectChemistry
dc.subjectBiochemistry
dc.subjectAlcaloides
dc.subjectNatural Sciences
dc.subjectKİMYA, MULTİDİSİPLİNER
dc.subjectTemel Bilimler (SCI)
dc.subjectCHEMISTRY, MULTIDISCIPLINARY
dc.subjectCHEMISTRY
dc.subjectNatural Sciences (SCI)
dc.subjectKimya (çeşitli)
dc.subjectGenel Kimya
dc.subjectFizik Bilimleri
dc.subjectChemistry (miscellaneous)
dc.subjectGeneral Chemistry
dc.subjectPhysical Sciences
dc.subjectBone Tissue Engineering
dc.subjectGraphene Oxide
dc.subjectHydroxyapatite (HA)
dc.subjectPolylactic acid (PLA)
dc.subjectScaffold
dc.subjectMECHANICAL-PROPERTIES
dc.subjectTISSUE
dc.subjectBONE
dc.subjectBIOMATERIALS
dc.subjectGRAPHENE
dc.subjectFABRICATION
dc.subjectSTRATEGIES
dc.subjectCOMPOSITE
dc.titleProduction and characterization of PLA/HA/GO nanocomposite scaffold
dc.typearticle
dspace.entity.typePublication
local.avesis.id7664d331-d824-4d76-b039-0ee8bfa1fbfd
local.indexed.atWOS
local.indexed.atSCOPUS
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication68c12e35-8bb7-4843-ab60-8b8339546e5f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

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