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Synthesis, characterization, crystal structure, electrochemical studies and biological evaluation of metal complexes with thiosemicarbazone of glyoxylic acid

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dc.contributor.authorÖZKAYA, ALİ RIZA
dc.contributor.authorsHuseynova, Mansura; Taslimi, Parham; Medjidov, Ajdar; Farzaliyev, Vagif; Aliyeva, Mahizar; Gondolova, Gulnar; Sahin, Onur; Yalcin, Bahattin; Sujayev, Afsun; Orman, Efe Baturhan; Ozkaya, Ali Riza; Gulcin, Ilhami
dc.date.accessioned2022-03-12T22:27:31Z
dc.date.available2022-03-12T22:27:31Z
dc.date.issued2018
dc.description.abstractCobalt and nickel nitrates form with thiosemicarbazone of glyoxylic acid (H(2)GAT) complexes of empirical composition Co(C3H4N3O2S)(2)center dot 2H(2)O, Ni(C3H4N3O2S)(2)center dot 2H(2)O and Ni(C3H6N3O2S)(2). X-ray diffraction studies have shown that the Co(HGAT)(2)center dot 2H(2)O, Ni(HGAT)(2)center dot 2H(2)O complexes are mononuclear, in which the coordination around the metal is octahedral, made up of two sulfur atoms, two nitrogen atoms and two oxygen atoms from two ligands. By the interaction of NiCl2 center dot H2O with 2-[2-(aminothioxomethyl)hydrazinyl] acetic acid (H(2)TAA) instead of the expected the metal thiosemicarbazonate complex with the hydrogenated on the azomethine group ligand was obtained. The redox properties of these compounds were also investigated by voltammetry on Pt in dimethylsulfoxide/tetrabutylammonium perchlorate. These thiosemicarbazone of glyoxylic acid derivatives had effective inhibition against alpha-glycosidase, cytosolic carbonic anhydrase I and II isoenzymes, butyrylcholinesterase and acetylcholinesterase. K-i values were found as 26.12-36.58 nM for hCA I, 20.73-40.78 nM for hCA II, 184.30-642.18 nM for AChE, 123.67-342.37 nM for BChE, and 14.66-45.62 nM for alpha-glycosidase. (C) 2018 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.poly.2018.08.026
dc.identifier.issn0277-5387
dc.identifier.urihttps://hdl.handle.net/11424/235212
dc.identifier.wosWOS:000449137000004
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofPOLYHEDRON
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectThiosemicarbazone
dc.subjectCarbonic anhydrase
dc.subjectCholinesterase
dc.subjectGlycosidase
dc.subjectEnzyme inhibition
dc.subjectCARBONIC-ANHYDRASE ISOENZYMES
dc.subjectNICKEL(II) COMPLEXES
dc.subjectINHIBITION PROFILES
dc.subjectHETEROCYCLIC THIOSEMICARBAZONES
dc.subjectBUTYRYLCHOLINESTERASE ENZYMES
dc.subjectACETYLCHOLINE ESTERASE
dc.subjectANTIOXIDANT
dc.subjectDERIVATIVES
dc.subjectBROMOPHENOLS
dc.subjectDISCOVERY
dc.titleSynthesis, characterization, crystal structure, electrochemical studies and biological evaluation of metal complexes with thiosemicarbazone of glyoxylic acid
dc.typearticle
dspace.entity.typePublication
local.avesis.id7ec9a4a6-e4b3-40fb-a05f-2bd6f568598b
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages9
local.journal.quartileQ2
oaire.citation.endPage33
oaire.citation.startPage25
oaire.citation.titlePOLYHEDRON
oaire.citation.volume155
relation.isAuthorOfPublication468ce3fe-dca4-4fd4-a890-3a220c85c8c9
relation.isAuthorOfPublication.latestForDiscovery468ce3fe-dca4-4fd4-a890-3a220c85c8c9

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