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Assessment of latent tuberculosis infection in Takayasu arteritis with tuberculin skin test and Quantiferon-TB Gold test

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dc.contributor.authorDİRESKENELİ, RAFİ HANER
dc.contributor.authorsKaradag, Omer; Aksu, Kenan; Sahin, Abdurrahman; Zihni, Figen Yargucu; Sener, Burcin; Inanc, Nevsun; Kalyoncu, Umut; Aydin, Sibel Zehra; Ascioglu, Sibel; Ocakci, Pinar Talu; Bilgen, Sule Apras; Keser, Gokhan; Inal, Vedat; Direskeneli, Haner; Calguneri, Meral; Ertenli, Ihsan; Kiraz, Sedat
dc.date.accessioned2022-03-12T17:48:28Z
dc.date.available2022-03-12T17:48:28Z
dc.date.issued2010
dc.description.abstractA possible relationship between Takayasu arteritis (TA) and tuberculosis (TB) has been suggested. An increased frequency of tuberculin skin test (TST) was observed in TA patients. Quantiferon-TB Gold test (QFT) is a new in vitro assay measuring interferon-gamma response to M. tuberculosis antigens and helpful in diagnosing latent TB infection. The aim of this study was to investigate latent TB infection among TA patients by the use of both TST and QFT Gold test. Ninety-four (male/female: 7/87) TA patients fulfilling ACR 1990 TA criteria from three different university hospitals in Turkey and 107 control subjects without inflammatory diseases were included in the study. Data about medical history (TA and TB) were collected for both groups. TST and QFT were performed. TST values a parts per thousand yen5 mm for TA patients and a parts per thousand yen15 mm for controls was accepted as TST positivity. Even though TA group was older (40 +/- A 12 vs. 32 +/- A 8, P < 0.001), there was no significant difference between TA patients and controls regarding demographic characteristics. Six TA patients and one control had a history of previous TB infection (P = 0.054). Although TST positivity was higher in TA group [55 patients (62.5%) vs. 24 controls (41.4%), P = 0.008], QFT positivity was similar between two groups [21 patients (22.3%) vs. 24 controls (22.4%), P > 0.05]. QFT was negative in two of six TA patients with previous TB history. Rate of latent TB infection in TA patients measured with QFT is no more than controls. QFT seems to be a good and favorable test compared with TST in detecting LTBI in TA.
dc.identifier.doi10.1007/s00296-010-1444-z
dc.identifier.issn0172-8172
dc.identifier.pubmed20358203
dc.identifier.urihttps://hdl.handle.net/11424/229961
dc.identifier.wosWOS:000281254400012
dc.language.isoeng
dc.publisherSPRINGER HEIDELBERG
dc.relation.ispartofRHEUMATOLOGY INTERNATIONAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTuberculosis
dc.subjectTakayasu arteritis
dc.subjectTuberculin skin test
dc.subjectQuantiferon-TB Gold test
dc.subjectINTERFERON-GAMMA ASSAY
dc.subjectAUTOIMMUNE-DISEASES
dc.subjectTHERAPY
dc.subjectTOOLS
dc.titleAssessment of latent tuberculosis infection in Takayasu arteritis with tuberculin skin test and Quantiferon-TB Gold test
dc.typearticle
dspace.entity.typePublication
local.avesis.id2b57f6d9-2493-499e-86b8-164190fa3d09
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages5
oaire.citation.endPage1487
oaire.citation.issue11
oaire.citation.startPage1483
oaire.citation.titleRHEUMATOLOGY INTERNATIONAL
oaire.citation.volume30
relation.isAuthorOfPublication07a34d26-21f3-475d-bd36-152d6c659370
relation.isAuthorOfPublication.latestForDiscovery07a34d26-21f3-475d-bd36-152d6c659370

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