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Humoral immune response to mycobacterial heat shock protein (hsp)65 in the cerebrospinal fluid of neuro-Behcet patients

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dc.contributor.authorDİRESKENELİ, RAFİ HANER
dc.contributor.authorsTasci, B; Direskeneli, H; Serdaroglu, P; Akman-Demir, G; Eraksoy, M; Saruhan-Direskeneli, G
dc.date.accessioned2022-03-14T09:05:07Z
dc.date.available2022-03-14T09:05:07Z
dc.date.issued2001-12-25
dc.description.abstractAlthough systemic immune reactivity to 65-kD mycobacterial hsp65 (m-hsp65) has been shown previously in Behcet's disease (BD), local immune response was not investigated. Mie studied anti-m-hsp65 IgG, IgM and IgA antibodies in the serum and cerebrospinal fluid (CSF) of 25 ED patients with cerebral parenchymal involvement (p-NBD), seven ED patients with intracranial hypertension (ih-NBD), eight BD patients without central nervous system (CNS) involvement, 30 patients with multiple sclerosis (MS) and 24 patients with non-inflammatory CNS disorders (NIC). Significantly higher CSF IgG responses were detected in p-NBD patients (ELISA ratio 1.3 +/- 0.9) compared with NIC (0.7 +/- 0.4, P < 0.01). In p-NBD patients' IgG, IgM or IgA CSF anti-m-hsp65 positivity rate was 48% (12/25); this was significantly higher when compared with MS (3/30; P < 0.03) and NIC (3/24; P < 0.01). CSF anti-m-hsp65 IgG ratios correlated with the duration of ED (r = 0.4, P < 0.04) but not with the duration of neurological involvement. Serum IBM and IgA responses were elevated in ih-NBD, suggesting a different type of involvement than p-NBD. These results implicate an increased local humoral response to m-hsp65 in the CSF of p-NBD patients, which might be related to the pathogenesis of neurological involvement.
dc.identifier.doi10.1046/j.1365-2249.1998.00620.x
dc.identifier.issn0009-9104
dc.identifier.pubmed9697991
dc.identifier.urihttps://hdl.handle.net/11424/242436
dc.identifier.wosWOS:000075101500016
dc.language.isoeng
dc.publisherBLACKWELL SCIENCE LTD
dc.relation.ispartofCLINICAL AND EXPERIMENTAL IMMUNOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectneuro-Behcet's disease
dc.subjectcerebrospinal fluid
dc.subjectheat shock protein 65
dc.subjectT-CELLS
dc.subjectMULTIPLE-SCLEROSIS
dc.subjectDISEASE
dc.subjectANTIBODIES
dc.subjectEXPRESSION
dc.subjectINVOLVEMENT
dc.subjectRECEPTOR
dc.subjectEPITOPE
dc.subjectANTIGEN
dc.subjectBLOOD
dc.titleHumoral immune response to mycobacterial heat shock protein (hsp)65 in the cerebrospinal fluid of neuro-Behcet patients
dc.typearticle
dspace.entity.typePublication
local.avesis.id0383d3a2-4b05-44b5-ba10-dd0db3e8bf3a
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages5
oaire.citation.endPage104
oaire.citation.issue1
oaire.citation.startPage100
oaire.citation.titleCLINICAL AND EXPERIMENTAL IMMUNOLOGY
oaire.citation.volume113
relation.isAuthorOfPublication07a34d26-21f3-475d-bd36-152d6c659370
relation.isAuthorOfPublication.latestForDiscovery07a34d26-21f3-475d-bd36-152d6c659370

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