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Preclinical studies on convalescent human immune plasma-derived exosome: Omics and antiviral properties to SARS-CoV-2

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dc.contributor.authorGÜL, FETHİ
dc.contributor.authorsTasli N. P., GÖNEN Z. B., Kirbas O. K., Gokdemir N. S., Bozkurt B. T., Bayrakci B., Sagrac D., Taskan E., Demir S., Gurcan N. E., et al.
dc.date.accessioned2023-05-08T08:08:21Z
dc.date.available2023-05-08T08:08:21Z
dc.date.issued2022-03-01
dc.description.abstractThe scale of the COVID-19 pandemic forced urgent measures for the development of new therapeutics. One of these strategies is the use of convalescent plasma (CP) as a conventional source for passive immunity. Recently, there has been interest in CP-derived exosomes. In this report, we present a structural, biochemical, and biological characterization of our proprietary product, convalescent human immune plasma-derived exosome (ChipEXO), following the guidelines set forth by the Turkish Ministry of Health and the Turkish Red Crescent, the Good Manufacturing Practice, the International Society for Extracellular Vesicles, and the Gene Ontology Consortium. The data support the safety and efficacy of this product against SARS-CoV-2 infections in preclinical models.
dc.identifier.citationTasli N. P., GÖNEN Z. B., Kirbas O. K., Gokdemir N. S., Bozkurt B. T., Bayrakci B., Sagrac D., Taskan E., Demir S., Gurcan N. E., et al., "Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2", FRONTIERS IN IMMUNOLOGY, cilt.13, 2022
dc.identifier.doi10.3389/fimmu.2022.824378
dc.identifier.issn1664-3224
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/43985437-9565-4e7d-a335-4e2c27532e5f/file
dc.identifier.urihttps://hdl.handle.net/11424/289168
dc.identifier.volume13
dc.language.isoeng
dc.relation.ispartofFRONTIERS IN IMMUNOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectLife Sciences
dc.subjectNatural Sciences
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectIMMUNOLOGY
dc.subjectLife Sciences (LIFE)
dc.subjectGenel İmmünoloji ve Mikrobiyoloji
dc.subjectGeneral Immunology and Microbiology
dc.subjectImmunology
dc.subjectexosome
dc.subjectextracellular vehicles (EVs)
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectconvalescence plasma
dc.subjectviral treatment
dc.subjectACUTE RESPIRATORY SYNDROME
dc.subjectVENTILATION
dc.subjectRESPONSES
dc.subjectVESICLES
dc.subjectexosome
dc.subjectextracellular vehicles (EVs)
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectconvalescence plasma
dc.subjectviral treatment
dc.titlePreclinical studies on convalescent human immune plasma-derived exosome: Omics and antiviral properties to SARS-CoV-2
dc.typearticle
dspace.entity.typePublication
local.avesis.id43985437-9565-4e7d-a335-4e2c27532e5f
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication907a6efd-2877-4832-b6a2-d87a28e52165
relation.isAuthorOfPublication.latestForDiscovery907a6efd-2877-4832-b6a2-d87a28e52165

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