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Influence of oral glycopeptides on the fecal flora of human volunteers: Selection of highly glycopeptide-resistant enterococci

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dc.contributor.authorKORTEN, VOLKAN
dc.contributor.authorsVan Der Auwera P., Pensart N., Korten V., Murray B.E., Leclercq R.
dc.date.accessioned2022-03-15T01:53:15Z
dc.date.available2022-03-15T01:53:15Z
dc.date.issued1996
dc.description.abstractChanges in fecal flora were evaluated in 22 healthy volunteers administered oral vancomycin or teicoplanin in 1989-1991 in Belgium. Evaluation of 5 colonies per subject revealed no glycopeptide-resistant enterococci in the predominant flora before glycopeptide administration; however, large numbers (mostly Enterococcus faecium) emerged by the end of the study in 14 (64%) of the subjects. Pediococci and lactobacilli also increased in number. In 1992, 40 healthy volunteers and 33 cancer patients were evaluated by plating stool samples directly onto selective media containing vancomyein; low numbers of vancomycin-resistant enterococci (<50 cfu/g) were found in 11 (28%) of the 40 and 4 (12%) of the 33 samples, respectively. DNA restriction fragment length polymorphism analysis showed that most isolates were different, but all contained vanA in Tn1546-like elements. These results indicate that vanA and Tn1546-like elements were common in Belgium as early as 1989 and that community-based individuals in that location likely form a major reservoir for glycopeptide-resistant enterococci.
dc.identifier.doi10.1093/infdis/173.5.1129
dc.identifier.issn221899
dc.identifier.pubmed8627064
dc.identifier.urihttps://hdl.handle.net/11424/246298
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofJournal of Infectious Diseases
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleInfluence of oral glycopeptides on the fecal flora of human volunteers: Selection of highly glycopeptide-resistant enterococci
dc.typearticle
dspace.entity.typePublication
local.avesis.idd8d85733-1071-4a08-9d1a-58abdc4f63a2
local.import.packageSS21
local.import.sourceScopus
local.indexed.atSCOPUS
oaire.citation.endPage1136
oaire.citation.issue5
oaire.citation.startPage1129
oaire.citation.titleJournal of Infectious Diseases
oaire.citation.volume173
relation.isAuthorOfPublication27f6afa3-0e46-45c9-a302-a6493c69bffb
relation.isAuthorOfPublication.latestForDiscovery27f6afa3-0e46-45c9-a302-a6493c69bffb

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