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Protective effects of St. John's wort in the hepatic ischemia/reperfusion injury in rats

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dc.contributor.authorVELİOĞLU ÖĞÜNÇ, AYLİZ
dc.contributor.authorsAtalay, Suleyman; Soylu, Belkis; Aykac, Asli; Ogunc, Ayliz Velioglu; Cetinel, Sule; Ozkan, Naziye; Erzik, Can; Sehirli, Ahmet Ozer
dc.date.accessioned2022-03-14T09:03:12Z
dc.date.available2022-03-14T09:03:12Z
dc.date.issued2018-09-28
dc.description.abstractObjectives: The purpose of this study was to investigate possible protective effects of St. John's wort in the hepatic ischemia/reperfusion injury. Material and Methods: The hepatic artery, portal vein, and bile duct were all clamped for 45 minutes to induce ischemia in rats, and after that reperfusion for 1 hour. SJW was administrated orally, once a day for 3 days before ischemia/reperfusion. The aspartate aminotransferase, alanine aminotransferase, tumor necrosis factor, and interleukin levels were measured in the serum samples. Luminol chemiluminescence, lucigenin luminol chemiluminescence levels; myeloperoxidase. The sodium-potassium ATPase (Na+/K+ ATPase) activity was determined in the liver tissue, and caspase-3 and caspase-9 activity with the bcl-2/bax ratio were measured by the western blot analysis. Results: The St. John's wort administration recovered the aspartate aminotransferase, alanine aminotransferase, tumor necrosis factor, and IL-1 beta levels serum parameters meaningfully, while ischemia/reperfusion caused an increase in luminol chemiluminescence, lucigenin luminol chemiluminescence, myeloperoxidase, caspase-3, and caspase-9 activity and led to a decrease in the B-cell lymphoma-2/bcl-2-associated X protein (bcl-2/bax) ratio and the Na+/K+ ATPase activity. Conclusion: The obtained results indicate protective effects of St. John's wort on the ischemia/reperfusion injury through various mechanisms, and we are able to suggest that St. John's wort can clinically create a new therapeutic principle.
dc.identifier.doi10.5152/turkjsurg.2018.3952
dc.identifier.eissn2564-7032
dc.identifier.issn2564-6850
dc.identifier.pubmed30216173
dc.identifier.urihttps://hdl.handle.net/11424/242232
dc.identifier.wosWOS:000446227800007
dc.language.isoeng
dc.publisherAVES
dc.relation.ispartofTURKISH JOURNAL OF SURGERY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectinflammatory
dc.subjectischemia/reperfusion
dc.subjectSt. John's wort
dc.subjectISCHEMIA-REPERFUSION INJURY
dc.subjectHEPATECTOMY
dc.subjectINDUCTION
dc.subjectMICE
dc.titleProtective effects of St. John's wort in the hepatic ischemia/reperfusion injury in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id7cf9e501-8e6f-4f34-a0d1-88578fa73711
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.indexed.atTRDIZIN
local.journal.numberofpages7
oaire.citation.endPage204
oaire.citation.issue3
oaire.citation.startPage198
oaire.citation.titleTURKISH JOURNAL OF SURGERY
oaire.citation.volume34
relation.isAuthorOfPublication13300bf6-ba96-4f87-9868-b0d2c86f572a
relation.isAuthorOfPublication.latestForDiscovery13300bf6-ba96-4f87-9868-b0d2c86f572a

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Department of General Surgery, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey et al. - 2018 - Protective effects of St. John’s wort in the hepat.pdf
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