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Solitary fibrous tumor of the pancreas: Analysis of 9 cases with literature review

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dc.contributor.authorŞAHİN ÖZKAN, HÜLYA
dc.contributor.authorBAĞCI ÇULÇİ, PELİN
dc.contributor.authorsYavas A., Tan J., Sahin Ozkan H., Yilmaz F., Reid M. D., Bagci P., Shi J., Shia J., Adsay V., Klimstra D. S., et al.
dc.date.accessioned2023-12-04T08:28:20Z
dc.date.available2023-12-04T08:28:20Z
dc.date.issued2023-11-01
dc.description.abstractSolitary fibrous tumor (SFT) has been increasingly reported in various anatomic sites. However, it is still extremely rare in the pancreas. Herein, we present the first series of primary pancreatic SFTs. Nine cases of primary pancreatic SFTs were analyzed. The mean age was 60 years (36 to 76 y) with no sex predilection. Six tumors were in the head, 3 were in the tail. On imaging studies, tumors were described as a hypervascular mass, 2 revealed cystic areas, and 3 were favored to be neuroendocrine tumors. On biopsy, 2 cases were diagnosed as atypical spindle cell tumor; one was misdiagnosed as suspicious for sarcoma, and another case as metastatic renal cell carcinoma. Two were diagnosed as low-grade sarcoma and low-grade stromal tumor on frozen sections. Grossly, tumors were well-demarcated with a median size of 4 cm (0.9 to 15 cm). Microscopically, they were composed of ovoid to spindle tumor cells with no significant mitotic activity and were arranged in alternating hypercellular and hypocellular areas. Staghorn-like vessels and entrapped pancreatic parenchyma were also detected within all tumors. Tumor cells revealed diffuse/strong nuclear STAT6 expression in 7 of 8, CD34 in 7 of 9, and bcl-2 in 4 of 4 tested cases. One tested tumor harbored NAB2-STAT6 fusion. Eight patients with available follow-up data were free of disease at a mean follow-up of 76 months (3 to 189 mo). SFT should be considered in the differential diagnoses of mesenchymal neoplasms of the pancreas. Immunohistochemical nuclear STAT6 expression is a characteristic feature of SFT. Primary pancreatic SFTs seem to have favorable biological behavior in our series.
dc.identifier.citationYavas A., Tan J., Sahin Ozkan H., Yilmaz F., Reid M. D., Bagci P., Shi J., Shia J., Adsay V., Klimstra D. S., et al., "Solitary Fibrous Tumor of the Pancreas: Analysis of 9 Cases with Literature Review", American Journal of Surgical Pathology, cilt.47, sa.11, ss.1230-1242, 2023
dc.identifier.doi10.1097/pas.0000000000002108
dc.identifier.endpage1242
dc.identifier.issn0147-5185
dc.identifier.issue11
dc.identifier.startpage1230
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85177585715&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/295303
dc.identifier.volume47
dc.language.isoeng
dc.relation.ispartofAmerican Journal of Surgical Pathology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectCerrahi Tıp Bilimleri
dc.subjectPatoloji
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectAnatomi
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectSurgery Medicine Sciences
dc.subjectPathology
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectHuman Anatomy
dc.subjectBiochemistry
dc.subjectNatural Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectBiyoloji ve Biyokimya
dc.subjectCERRAHİ
dc.subjectPATOLOJİ
dc.subjectANATOMİ VE MORFOLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectLife Sciences (LIFE)
dc.subjectCLINICAL MEDICINE
dc.subjectBIOLOGY & BIOCHEMISTRY
dc.subjectSURGERY
dc.subjectPATHOLOGY
dc.subjectANATOMY & MORPHOLOGY
dc.subjectCerrahi
dc.subjectPatoloji ve Adli Tıp
dc.subjectAnatomy
dc.subjectSurgery
dc.subjectPathology and Forensic Medicine
dc.subjectmesenchymal tumor
dc.subjectpancreas
dc.subjectpancreatic
dc.subjectsolitary fibrous tumor
dc.titleSolitary fibrous tumor of the pancreas: Analysis of 9 cases with literature review
dc.typearticle
dspace.entity.typePublication
local.avesis.id0974a976-8a78-48c3-a3c6-9c5a81f16ca4
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication6be2cb2f-b47c-4e15-87e8-f51f26f90906
relation.isAuthorOfPublication08d32d97-3eab-4e66-9cb5-3177601d83e9
relation.isAuthorOfPublication.latestForDiscovery6be2cb2f-b47c-4e15-87e8-f51f26f90906

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