Publication: Development of gallic acid-loaded ethylcellulose fibers as a potential wound dressing material
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Date
2023-09-18
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Abstract
In this study, novel fibers were designed based on ethylcellulose (EC), loaded with different
concentrations of gallic acid (GA) using the electrospinning technique, in order to investigate the
potential of these materials as wound dressings. The chemical structure and morphology, along with
the antimicrobial and biocompatibility tests of the EC_GA fibers were investigated. To observe the
chemical interactions between the components, fourier transform infrared spectroscopy (FTIR) was
used. The morphological analyzes were performed using scanning electron microscope (SEM). The
uniaxial tensile test machine was used to obtain mechanical performance of the fibers. MTT assay was
applied to get the biocompatibility properties of the fibers and antimicrobial test was applied to obtain
the antimicrobial activity of the fibers. Based on the obtained results, the highest viability value of
67.4% was obtained for 10%EC_100GA on the third day of incubation, demonstrating that with the addition of a higher concentration of GA, the cell viability increases. The antimicrobial tests, evaluated
against Staphylococcus (S.) aureus, Escherichia (E.) coli, Pseudomonas (Ps.) aeruginosa and Candida
(C.) albicans, showed a >90% microbial reduction capacity correlated with a logarithmic reduction
ranging from 0.63 to 1, for 10%EC_100 GA. In vitro release tests of GA from the fibers showed that
GA was totally released from 10%EC_100 GA fibers after 2880 minutes, demonstrating a controlled
release profile. These findings demonstrated that EC_GA fibers may be suitable for application in
biomedical fields such as wound dressing materials. However, further studies should be performed to
increase the biocompatibility properties of the fibers.
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Keywords
Electrospinning, ethylcellulose, fiber, gallic acid, tissue engineering, wound healing
Citation
Croitoru A., Ayran M., Altan E., Karacelebi Y., Ulag S., Sahin A., Guncu M. M., Aksu B., Gunduz O., Tihăuan B., et al., "Development of gallic acid-loaded ethylcellulose fibers as a potential wound dressing material.", International journal of biological macromolecules, ss.126996, 2023