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3D Propolis-Sodium Alginate Scaffolds: Influence on Structural Parameters, Release Mechanisms, Cell Cytotoxicity and Antibacterial Activity

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dc.contributor.authorAKSU, MEHMET BURAK
dc.contributor.authorsAranci, Kubra; Uzun, Muhammet; Su, Sena; Cesur, Sumeyye; Ulag, Songul; Amin, Al; Guncu, Mehmet Mucahit; Aksu, Burak; Kolayli, Sevgi; Ustundag, Cem Bulent; Silva, Jorge Carvalho; Ficai, Denisa; Ficai, Anton; Gunduz, Oguzhan
dc.date.accessioned2022-03-14T09:26:13Z
dc.date.available2022-03-14T09:26:13Z
dc.date.issued2020-11-02
dc.description.abstractIn this study, the main aim was to fabricate propolis (Ps)-containing wound dressing patches using 3D printing technology. Different combinations and structures of propolis (Ps)-incorporated sodium alginate (SA) scaffolds were developed. The morphological studies showed that the porosity of developed scaffolds was optimized when 20% (v/v) of Ps was added to the solution. The pore sizes decreased by increasing Ps concentration up to a certain level due to its adhesive properties. The mechanical, swelling-degradation (weight loss) behaviors, and Ps release kinetics were highlighted for the scaffold stability. An antimicrobial assay was employed to test and screen antimicrobial behavior of Ps against Escherichia coli and Staphylococcus aureus strains. The results show that the Ps-added scaffolds have an excellent antibacterial activity because of Ps compounds. An in vitro cytotoxicity test was also applied on the scaffold by using the extract method on the human dermal fibroblasts (HFFF2) cell line. The 3D-printed SA-Ps scaffolds are very useful structures for wound dressing applications.
dc.identifier.doi10.3390/molecules25215082
dc.identifier.eissn1420-3049
dc.identifier.pubmed33147742
dc.identifier.urihttps://hdl.handle.net/11424/243119
dc.identifier.wosWOS:000589285700001
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofMOLECULES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject3D printing
dc.subjectpropolis
dc.subjectsodium alginate
dc.subjecttissue scaffold
dc.subjectwound treatment
dc.subjectBRAZILIAN RED PROPOLIS
dc.subjectIN-VITRO
dc.subjectBIOLOGICAL-PROPERTIES
dc.subjectCHEMICAL-COMPOSITION
dc.subjectANTIVIRAL ACTIVITY
dc.subjectDRESSINGS
dc.subjectFILMS
dc.subjectANTIOXIDANT
dc.subjectEXTRACTS
dc.subjectDEGRADATION
dc.title3D Propolis-Sodium Alginate Scaffolds: Influence on Structural Parameters, Release Mechanisms, Cell Cytotoxicity and Antibacterial Activity
dc.typearticle
dspace.entity.typePublication
local.avesis.idab5b8e48-4ec6-4d57-8479-de86aa1912f8
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber5082
local.journal.numberofpages22
local.journal.quartileQ2
oaire.citation.issue21
oaire.citation.titleMOLECULES
oaire.citation.volume25
relation.isAuthorOfPublicationf7de5699-7a5c-4496-93cf-d8daba79da4f
relation.isAuthorOfPublication.latestForDiscoveryf7de5699-7a5c-4496-93cf-d8daba79da4f

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